Environmental factors dominate microbial community puppet-like driving the distribution of antibiotic resistance genes in different utilization lands

文献类型： 外文期刊

第一作者： Wang, Jiarui

作者： Wang, Jiarui;Li, Houyu;Yang, Qifan;Xu, Yan;Zheng, Xiangqun;Lu, Xing

作者机构：

关键词： Antibiotic resistance genes; Microorganism; Environmental variables; Land utilization patterns

期刊名称：ENVIRONMENTAL TECHNOLOGY & INNOVATION （ 影响因子：7.1； 五年影响因子：6.9 ）

ISSN： 2352-1864

年卷期： 2024 年 34 卷

页码：

收录情况： SCI

摘要： Excessive use of antibiotics has caused the accumulation of antibiotic resistance genes (ARGs) in the soil environment, posing a great challenge to environmental safety and public health. However, there is a lack of comprehensive investigations of soil ARGs profiles under different land utilization patterns, and the drivers that affect the distribution of ARGs remain poorly defined. Herein, we investigated the ARGs profiles of eight different land uses and explored the critical factors influencing the distribution of ARGs. The results showed that ARGs abundance in soil of parks, residential areas, farmland, and vegetable cultivation was significantly higher than that in other lands, with an average of 2.08 x 10(3) copies/g dry soil. The structural equation model demonstrated that the environmental variables were the pivotal drivers that dominated the differences in ARG distribution across land utilization types (path coefficient=0.934), in which the physicochemical factors exhibited the greatest contribution with an explanatory rate of 20.27%, which was markedly higher than that of antibiotics and heavy metal residues. Importantly, these physicochemical factors manipulate the succession of microbial communities by altering the connections between microorganisms, which in turn indirectly affects the distribution of ARGs. Moreover, ARG exposure was strongly correlated with fertilizer application, precipitation, and per capita water resources (p < 0.01). Overall, this study provides a well-rounded understanding of ARG exposure under different land-use patterns, which helps to develop management strategies for curbing ARGs dissemination in the environment.

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