Recent Advances in Fluorescent Methods for Polyamine Detection and the Polyamine Suppressing Strategy in Tumor Treatment

文献类型： 外文期刊

第一作者： Lu, Bingli

作者： Lu, Bingli;Wang, Lingyun;Tang, Hao;Cao, Derong;Ran, Xueguang

作者机构：

关键词： polyamines; detection; suppressor strategies; tumor

期刊名称：BIOSENSORS-BASEL （ 影响因子：5.743； 五年影响因子：5.972 ）

ISSN：

年卷期： 2022 年 12 卷 8 期

页码：

收录情况： SCI

摘要： The biogenic aliphatic polyamines (spermine, spermidine, and putrescine) are responsible for numerous cell functions, including cell proliferation, the stabilization of nucleic acid conformations, cell division, homeostasis, gene expression, and protein synthesis in living organisms. The change of polyamine concentrations in the urine or blood is usually related to the presence of malignant tumors and is regarded as a biomarker for the early diagnosis of cancer. Therefore, the detection of polyamine levels in physiological fluids can provide valuable information in terms of cancer diagnosis and in monitoring therapeutic effects. In this review, we summarize the recent advances in fluorescent methods for polyamine detection (supramolecular fluorescent sensing systems, fluorescent probes based on the chromophore reaction, fluorescent small molecules, and fluorescent nanoparticles). In addition, tumor polyamine-suppressing strategies (such as polyamine conjugate, polyamine analogs, combinations that target multiple components, spermine-responsive supramolecular chemotherapy, a combination of polyamine consumption and photodynamic therapy, etc.) are highlighted. We hope that this review promotes the development of more efficient polyamine detection methods and provides a comprehensive understanding of polyamine-based tumor suppressor strategies.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序