Two new 2-(2-Hydroxy-2-phenylethyl)chromens from agarwood originating from Aquilaria crassna

文献类型： 外文期刊

第一作者： Wang, Hong-Ni

作者： Wang, Hong-Ni;Mei, Wen-Li;Dong, Wen-Hua;Kong, Fan-Dong;Li, Wei;Yuan, Jing-Zhe;Dai, Hao-Fu

作者机构：

关键词： Thymelaeaceae;Aquilaria crassna;agarwood 2-(2-hydroxy-2-phenylethyl)chromone;acetylcholinesterase inhibition activity;antibacterial activity

期刊名称：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH （ 影响因子：1.569； 五年影响因子：1.598 ）

ISSN： 1028-6020

年卷期： 2018 年 20 卷 2 期

页码：

收录情况： SCI

摘要： Two new 2-(2-hydroxy-2-phenylethyl)chromones (1-2), along with three known 2-(2-phenylethyl)chromones (3-5), were isolated from the agarwood originating from Aquilaria crassna Pierre ex Lecomte. Their structures were determined by the spectroscopic methods including 1D and 2D NMR analysis and comparison with reported data in the literature. All the compounds were isolated from agarwood of A. crassna for the first time. Compounds 1 and 2 exhibited inhibitory activity against acetylcholinesterase (AChE) with 17.4 +/- 0.6 and 15.8 +/- 0.7%, respectively, at a concentration of 50 mu g/ml. Besides, Compound 3 expressed antibacterial activities against Ralstonia solanacearum with diameter of the inhibition zone of 6.80 +/- 0.08 mm at a concentration of 10 mg/ml. [GRAPHICS] .

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