Dimeric sesquiterpenoid-4&ITH&IT-chromone derivatives from agarwood of &ITAquilaria crassna&IT and their cytotoxicity

文献类型： 外文期刊

第一作者： Yang, Yang

作者： Yang, Yang;Chen, Hui-Qin;Kong, Fan-Dong;Zhou, Li-Man;Li, Wei;Dong, Wen-Hua;Mei, Wen-Li;Dai, Hao-Fu;Yang, Yang;Chen, Zhi-Bao

作者机构：

关键词： Aquilaria crassna;Thymelaeaceae;Agarwood;Dimeric compounds;Cytotoxicity

期刊名称：PHYTOCHEMISTRY （ 影响因子：4.072； 五年影响因子：4.132 ）

ISSN： 0031-9422

年卷期： 2018 年 145 卷

页码：

收录情况： SCI

摘要： Six previously undescribed uncommon ester-bonded dimeric compounds (aquilacrassnins A-F) containing a sesquiterpenoid and a 5,6,7,8-tetrahydroxy-2-(2-phenylethyl)-5,6,7,8-tetrahydro-4H-chromone units were isolated from the EtOAc extract of agarwood originating from Aquilaria crassna. Their structures were elucidated by spectroscopic (NMR, UV, IR, MS, and ECD) methods. All the compounds were tested for AChE inhibitory activity and cytotoxicity against K562, BEL-7402, SGC-7901, Hela, and A549 tumor cell lines. The results showed that aquilacrassnin A, B, and E exhibited weak cytotoxicity against the five tested cell lines, whereas all the compounds were inactive against AChE. (C) 2017 Published by Elsevier Ltd.

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