Metabolites with Insecticidal Activity from Aspergillus fumigatus JRJ111048 Isolated from Mangrove Plant Acrostichum specioum Endemic to Hainan Island

文献类型: 外文期刊

第一作者: Guo, Zhikai

作者: Guo, Zhikai;Gai, Cuijuan;Cai, Caihong;Chen, Liangliang;Liu, Shoubai;Zeng, Yanbo;Yuan, Jingzhe;Mei, Wenli;Dai, Haofu;Guo, Zhikai;Gai, Cuijuan;Cai, Caihong;Chen, Liangliang;Liu, Shoubai;Zeng, Yanbo;Yuan, Jingzhe;Mei, Wenli;Dai, Haofu

作者机构:

关键词: Acrostichum specioum;mangrove endophyte;Aspergillus fumigatus;anhydride;fatty acid amide;insecticidal activity;antifungal activity

期刊名称:MARINE DRUGS ( 影响因子:5.118; 五年影响因子:5.951 )

ISSN: 1660-3397

年卷期: 2017 年 15 卷 12 期

页码:

收录情况: SCI

摘要: Fungi residing in mangroves are considered to be a bank of novel bioactive natural products. In the screening for bioactive metabolites from mangrove-derived fungi, the ethyl acetate extract of the fermentation broth of Aspergillus fumigatus JRJ111048, a fungus isolated from the leaves of the mangrove plant Acrostichum specioum endemic to Hainan island, was found to possess insecticidal activity against Spodoptera litura. Bioactivity-guided isolation lead to the discovery of seven metabolites 1-7, including one new anhydride derivative aspergide (1), one new lipid amide 11-methyl-11-hydroxyldodecanoic acid amide (2), and five known compounds; -ethyl glucoside (3), spiculisporic acid B (4), spiculisporic acid C (5), spiculisporic acid (6), and secospiculisporic acid B (7). Their structures were established by NMR spectroscopic and MS analyses, and by comparison of previously reported data. Insecticidal activity against S. litura and antifungal activity of these compounds were investigated. As a result, the new compound 1 showed potent insecticidal activity against newly hatched larvae of S. litura, and compound 4 displayed weak antifungal activity against Candida albicans.

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