Manufacturing Techniques and Surface Engineering of Polymer Based Nanoparticles for Targeted Drug Delivery to Cancer

文献类型： 外文期刊

第一作者： Wang, Yichao

作者： Wang, Yichao;Wang, Yichao;Li, Puwang;Thao Truong-Dinh Tran;Zhang, Juan;Kong, Lingxue;Li, Puwang;Thao Truong-Dinh Tran

作者机构：

关键词： nanoparticles;PLGA;chitosan;nano;microencapsulation;drug delivery;top-down fabrication techniques

期刊名称：NANOMATERIALS （ 影响因子：5.076； 五年影响因子：5.346 ）

ISSN： 2079-4991

年卷期： 2016 年 6 卷 2 期

页码：

收录情况： SCI

摘要： The evolution of polymer based nanoparticles as a drug delivery carrier via pharmaceutical nano/microencapsulation has greatly promoted the development of nano- and micro-medicine in the past few decades. Poly(lactide-co-glycolide) (PLGA) and chitosan, which are biodegradable and biocompatible polymers, have been approved by both the Food & Drug Administration (FDA) and European Medicine Agency (EMA), making them ideal biomaterials that can be advanced from laboratory development to clinical oral and parental administrations. PLGA and chitosan encapsulated nanoparticles (NPs) have successfully been developed as new oral drug delivery systems with demonstrated high efficacy. This review aims to provide a comprehensive overview of the fabrication of PLGA and chitosan particulate systems using nano/microencapsulation methods, the current progress and the future outlooks of the nanoparticulate drug delivery systems. Especially, we focus on the formulations and nano/micro-encapsulation techniques using top-down techniques. It also addresses how the different phases including the organic and aqueous ones in the emulsion system interact with each other and subsequently influence the properties of the drug delivery system. Besides, surface modification strategies which can effectively engineer intrinsic physicochemical properties are summarised. Finally, future perspectives and potential directions of PLGA and chitosan nano/microencapsulated drug systems are outlined.

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