Efficient inactivation of African swine fever virus by a highly complexed iodine

文献类型： 外文期刊

第一作者： Pan, Li

作者： Pan, Li;Luo, Rui;Wang, Tao;Qi, Mengnan;Wang, Bing;Sun, Maowen;Luo, Yuzi;Sun, Yuan;Qiu, Hua-Ji;Luo, Rui;Qiu, Hua-Ji;Ji, Chen

作者机构：

关键词： Highly complexed iodine; African swine fever virus; Inactivation; Disinfectant

期刊名称：VETERINARY MICROBIOLOGY （ 影响因子：3.293； 五年影响因子：3.599 ）

ISSN： 0378-1135

年卷期： 2021 年 263 卷

页码：

收录情况： SCI

摘要： African swine fever (ASF) is a highly lethal contagious disease of swine caused by African swine fever virus (ASFV). Cleaning and disinfection remain one of the most effective tools to prevent the ASFV spread in pig holdings. This study evaluated the inactivation effect of a highly complexed iodine (HPCI) disinfectant against ASFV. A commercially available povidone-iodine (PVP-I) was used as reference for comparison. The results showed that 5% HPCI and 5% PVP-I did not exhibit cytotoxicity in primary porcine alveolar macrophages, and 107.0 and 105.0 TCID50/mL ASFV were completely inactivated by 5% and 0.25% HPCI, respectively, in 5 min via either immersion or spray disinfection. However, 5% PVP-I required at least 15 min to completely inactivate 107.0 TCID50/mL ASFV, whereas 0.25% PVP-I failed to completely inactivate 105.0 TCID50/mL ASFV. This study demonstrated that HPCI could rapidly and efficiently inactivate ASFV, representing an effective disinfectant for ASF control.

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