Aromatic compounds from the halotolerant fungal strain of Wallemia sebi PXP-89 in a hypersaline medium
文献类型: 外文期刊
第一作者: Peng, Xiao-Ping
作者: Peng, Xiao-Ping;Wang, Yi;Liu, Pei-Pei;Yin, Xia;Zhu, Wei-Ming;Hong, Kui;Chen, Hao
作者机构:
关键词: Halotolerant fungus;Wallemia sebi;Antibacterial activity;Cyclopentanopyridine alkaloid
期刊名称:ARCHIVES OF PHARMACAL RESEARCH ( 影响因子:4.946; 五年影响因子:3.483 )
ISSN: 0253-6269
年卷期: 2011 年 34 卷 6 期
页码:
收录情况: SCI
摘要: A new cyclopentanopyridine alkaloid, 3-hydroxy-5-methyl-5,6-dihydro-7H-cyclopenta[b]pyridin-7-one (1), together with 11 known aromatic compounds were isolated from the secondary metabolites of the halotolerant fungal strain Wallemia sebi PXP-89 in 10% NaCl. Their structures including the absolute configurations of (2S,3S)-1-(4-hydroxyphenyl)butane-2,3-diol (2), (2R,3S)-1-(4-hydroxyphenyl)butane-2,3-diol (3), and (S)-3-hydroxy-4-(4-hydroxyphenyl)-2-one (4) were elucidated by spectroscopic analysis and a modified Mosher's method. Compound 1 exhibited antimicrobial activity against Enterobacter aerogenes with a MIC of 76.7 mu M. The absolute configurations of compounds 2-4 were determined for the first time.
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