Benzamides and Quinazolines from a Mangrove Actinomycetes Streptomyces sp (No. 061316) and Their Inhibiting Caspase-3 Catalytic Activity in Vitro
文献类型: 外文期刊
第一作者: Chen, Guodong
作者: Chen, Guodong;Gao, Hao;Tang, Jinshan;Huang, Yuanfan;Chen, Ying;Wang, Ying;Zhao, Huinan;Yao, Xinsheng;Lin, Haipeng;Xie, Qingyi;Hong, Kui;Gao, Hao;Li, Jia
作者机构:
关键词: Streptomyces sp.;benzamide;quinazoline;Caspase-3
期刊名称:CHEMICAL & PHARMACEUTICAL BULLETIN ( 影响因子:1.645; 五年影响因子:1.613 )
ISSN: 0009-2363
年卷期: 2011 年 59 卷 4 期
页码:
收录情况: SCI
摘要: One new benzamide,, 3-hydroxyl-2-N-iso-butyryl-anthranilamide (1), together with two known benzamides (2, 3) and three known quinazolines (4-6), was isolated from a mangrove actinomycetes Streptomyces sp. (No. 061316), which displayed inhibiting Caspase-3 activity in vitro. The structure of 1 was elucidated by electrospray ionization (ESI)-MS, NMR spectroscopies and X-ray crystal diffraction. After evaluation of all compounds for their inhibitory effect on,Caspase-3 in vitro, 3-hydroxyl-anthranilamide (2) and 8-hydroxyl-2,4-dioxoquinazoline (6) showed activity against Caspase-3 with IC50 values of 32 and 36 mu M, respectively.
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