Benzamides and Quinazolines from a Mangrove Actinomycetes Streptomyces sp (No. 061316) and Their Inhibiting Caspase-3 Catalytic Activity in Vitro

文献类型: 外文期刊

第一作者: Chen, Guodong

作者: Chen, Guodong;Gao, Hao;Tang, Jinshan;Huang, Yuanfan;Chen, Ying;Wang, Ying;Zhao, Huinan;Yao, Xinsheng;Lin, Haipeng;Xie, Qingyi;Hong, Kui;Gao, Hao;Li, Jia

作者机构:

关键词: Streptomyces sp.;benzamide;quinazoline;Caspase-3

期刊名称:CHEMICAL & PHARMACEUTICAL BULLETIN ( 影响因子:1.645; 五年影响因子:1.613 )

ISSN: 0009-2363

年卷期: 2011 年 59 卷 4 期

页码:

收录情况: SCI

摘要: One new benzamide,, 3-hydroxyl-2-N-iso-butyryl-anthranilamide (1), together with two known benzamides (2, 3) and three known quinazolines (4-6), was isolated from a mangrove actinomycetes Streptomyces sp. (No. 061316), which displayed inhibiting Caspase-3 activity in vitro. The structure of 1 was elucidated by electrospray ionization (ESI)-MS, NMR spectroscopies and X-ray crystal diffraction. After evaluation of all compounds for their inhibitory effect on,Caspase-3 in vitro, 3-hydroxyl-anthranilamide (2) and 8-hydroxyl-2,4-dioxoquinazoline (6) showed activity against Caspase-3 with IC50 values of 32 and 36 mu M, respectively.

分类号:

  • 相关文献

[1]Programmed cell death in Laminaria japonica (Phaeophyta) tissues infected with alginic acid decomposing bacterium. Wang, GG,Lin, W,Zhang, LJ,Yan, XJ,Duan, DL. 2004

[2]Cloning of a New Xylanase Gene from Streptomyces sp TN119 Using a Modified Thermal Asymmetric Interlaced-PCR Specific for GC-Rich Genes and Biochemical Characterization. Zhou, Junpei,Huang, Huoqing,Meng, Kun,Shi, Pengjun,Wang, Yaru,Luo, Huiying,Yang, Peilong,Bai, Yingguo,Yao, Bin. 2010

[3]A new fungicide produced by a Streptomyces sp GAAS7310. Chen, GY,Lin, BR,Lin, YC,Xie, FC,Lu, W,Fong, WF. 2005

[4]A new degraded sesquiterpene from marine actinomycete Streptomyces sp 0616208. Xie, Xiu Chao,Mei, Wen Li,Zhao, You Xing,Hong, Kui,Dai, Hao Fu. 2006

[5]Rhizoma smilacis glabrae protects rats with gentamicin-induced kidney injury from oxidative stress-induced apoptosis by inhibiting caspase-3 activation. Liu, Cuiyan,Kang, Youxi,Yang, Zisheng,Han, Chunyang,Zhou, Xiuhong,Gu, Jingang.

[6]Paromomycin Derived from Streptomyces sp AG-P 1441 Induces Resistance against Two Major Pathogens of Chili Pepper. Sang, Mee Kyung,Park, Kyungseok,Kim, Chang-Jin,Park, Dong-Jin,Nam, Ki-Woong,Zhang, Kecheng.

[7]Study on the Role of Caspase-3 at Longan Pulp Autolysis. Wu, Z. X.,Chen, Z. J.,Zhang, H. Y.,Han, D. M.,Li, J. G.. 2010

[8]Oridonin-induced apoptosis in SW620 human colorectal adenocarcinoma cells. Ji, Zhe,Tang, Qingjiu,Zhang, Jinsong,Yang, Yan,Liu, Yanfang,Ji, Zhe,Pan, Yingjie. 2011

[9]Effects of calcium and zinc ions injection on caspase-3 activation and tenderness in post-mortem beef skeletal muscles. Huang, Feng,Ding, Zhenjiang,Zhang, Chunjiang,Hu, Honghai,Zhang, Liang,Zhang, Hong,Huang, Feng,Zhang, Chunjiang,Hu, Honghai,Zhang, Liang,Zhang, Hong,Huang, Feng,Zhang, Chunjiang,Hu, Honghai,Zhang, Liang,Zhang, Hong. 2018

[10]Effect of heat shock protein 27 on the invitro degradation of myofibrils by caspase-3 and -calpain. Ding, Zhenjiang,Huang, Feng,Zhang, Chunjiang,Zhang, Liang,Sun, Hongxia,Zhang, Hong,Huang, Feng,Zhang, Chunjiang,Zhang, Liang,Zhang, Hong,Huang, Feng,Zhang, Chunjiang,Zhang, Liang,Zhang, Hong. 2018

[11]D-chiro-inositol enriched Fagopyrum tataricum (L.) Gaench extract alleviates mitochondria' malfunction and inhibits ER stress/JNK associated inflammation in the endothelium. Zhang, Bobo,Gao, Caifeng,Wang, Min,Li, Yunlong. 2018

[12]A new staurosporine analog from Actinomycetes Streptomyces sp (172614). Li, Xiao-Bin,Tang, Jin-Shan,Gao, Hao,Yao, Xin-Sheng,Ding, Rong,Yao, Xin-Sheng,Li, Jia,Hong, Kui. 2011

[13]Cytotoxic Constituents from Marine Actinomycete Streptomyces sp 124092. Xie Xiu-Chao,Mei Wen-Li,Zeng Yan-Bo,Lin Hai-Peng,Zhuang Ling,Dai Hao-Fu,Hong Kui,Xie Xiu-Chao. 2008

[14]Effects of PEGylated porcine glucagon-like peptide-2 therapy in weaning piglets challenged with lipopolysaccharide. Qi, Ke-ke,Wu, Jie,Xu, Zi-wei.

[15]Inducing secondary metabolite production by the soil-dwelling fungus Aspergillus terreus through bacterial co-culture. Chen, Huiqin,Daletos, Georgios,Proksch, Peter,Abdel-Aziz, Mohamed S.,Thomy, Dhana,Broetz-Oesterhelt, Heike,Chen, Huiqin,Dai, Haofu,Lin, Wenhan.

作者其他论文 更多>>