A novel antibiotic produced by streptomyces noursei Da07210
文献类型: 外文期刊
第一作者: Wu, Xiaopeng
作者: Wu, Xiaopeng;Huang, Huiqin;Sun, Qianguang;Peng, Jie;Zhu, Jun;Bao, Shixiang;Chen, Guangying
作者机构:
关键词: Antifungal activity;Fungicide;Antitumor activity;Actinomycete
期刊名称:ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY ( 影响因子:2.271; 五年影响因子:2.707 )
ISSN: 0003-6072
年卷期: 2009 年 96 卷 1 期
页码:
收录情况: SCI
摘要: A novel antibiotic 210-A, named as (6S,8aS,9S,11S,12aR)-6-hydroxy-9,10-dimethyldecahydrobenzo[d]azecine-2,4,12(3H)-trione, was isolated from the fermentation broth of Streptomyces noursei Da07210, its structure was unambiguously established by spectral analyses and chemical comparison with related cycloheximide. Experiments demonstrated that 210-A bore strong activity against Fusarium oxysporum f. sp. cubense race four (Foc race four), which also showed antitumor activity against SMMC-7721 human hepatocarcinoma cells and S180 murine sarcoma, and the IC(50) values were 0.77 and 0.74 mu g/ml, respectively.
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