Cytotoxic prenylated xanthones from Calophyllum inophyllum

文献类型: 外文期刊

第一作者: Xiao, Qi

作者: Xiao, Qi;Zeng, Yan-Bo;Mei, Wen-Li;Deng, Yuan-Yuan;Dai, Hao-Fu;Zhao, You-Xing

作者机构:

关键词: Calophyllum inophyllum;cytotoxic activity;prenylated xanthone;caloxanthone N

期刊名称:JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH ( 影响因子:1.569; 五年影响因子:1.598 )

ISSN: 1028-6020

年卷期: 2008 年 10 卷 10 期

页码:

收录情况: SCI

摘要: A new prenylated xanthone (1), named caloxanthone N, together with two known constituents, gerontoxanthone C (2) and 2-hydroxyxanthone (3), was isolated from the ethanolic extract of the twigs of Calophyllum inophyllum. Their structures were completely elucidated using a combination of 1D, 2D NMR techniques (COSY, HMQC, HMBC, and ROESY) and HR-ESI-MS analyses. Compounds 1 and 2 exhibited cytotoxicity against chronic myelogenous leukemia cell line (K562) with IC50 values of 7.2 and 6.3gml-1, respectively.

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