Identification and functional analysis of a novel single nucleotide polymorphism (SNP) in the porcine Toll like receptor (TLR) 5 gene

文献类型： 外文期刊

第一作者： Li, H. -T.

作者： Li, H. -T.;Yang, X. -Q.;Liu, D.

作者机构：

关键词： Porcine;TLR5;SNP;function

期刊名称：ACTA AGRICULTURAE SCANDINAVICA SECTION A-ANIMAL SCIENCE （ 影响因子：0.684； ）

ISSN： 0906-4702

年卷期： 2011 年 61 卷 4 期

页码：

收录情况： SCI

摘要： Toll like receptor (TLR) 5, recognizing bacterial flagellin, plays an important role in immune systems. Single nucleotide polymorphisms (SNPs) in TLR5 gene may alter host immune response to flagellin and have an effect on susceptibility to infectious disease, as suggested by studies in humans and other animals. Here, a novel nonsynonymous SNP, G2239A leading to the transformation of Val by Met at the 747th amino acid, was first identified in TIR domain of porcine TLR5 gene. To examine whether SNP G2239A is functionally relevant, eukaryotic expression vector with site-directed mutagenesis at the site was constructed and its ability to activate the expression of TLR5-dependent reporter constructs was tested. Variant notably diminished the activation of reporter gene (p < 0.05) when compared with wild type TLR5. SNP G2239A has an effect on the receptor function.

分类号：

  • 相关文献

[1]Characterization and functional significance of polymorphisms in porcine Toll-like receptor (TLR) 5 gene. Li, Hai-tao,Yang, Xiu-qin,Wang, Liang,Liu, Di. 2012

[2]Genetic diversity of Toll-like receptor 5 among pig populations. Yang, Xiuqin,Li, Haitao,Guan, Qingzhi,Liu, Di. 2013

[3]Molecular Characterization, Expression Patterns, and Association Analysis with Carcass Traits of Porcine USF1 Gene. Wu, Huayu,Qiao, Mu,Peng, Xianwen,Wu, Junjing,Liu, Guisheng,Sun, Hua,Li, Lianghua,Mei, Shuqi. 2013

[4]Polymorphism and association analysis with carcass traits of porcine USF1 gene. Wu, Hua-Yu,Qiao, Mu,Peng, Xian-Wen,Wu, Jun-Jing,Liu, Gui-Sheng,Sun, Hua,Li, Liang-Hua,Mei, Shu-Qi.

[5]Molecular characterisation and functional analysis of a cytochrome P450 gene in cotton. Zhou, Kexue,Long, Lu,Sun, Quan,Wang, Weina,Gao, Wei,Cai, Chaowei,Mo, Jianchuan,Cheng, Jieru,Zhang, Xiangrui,Liu, Yujia,Miao, Chen,Zhang, Xiao,Cai, Yingfan,Du, Xiongming,Shi, Yuzhen,Yuan, Youlu,Chu, Zongyan.

[6]Comparative Proteomic Analysis Reveals Differential Root Proteins in Medicago sativa and Medicago truncatula in Response to Salt Stress. Long, Ruicai,Zhang, Tiejun,Kang, Junmei,Cong, Lili,Gao, Yanli,Yang, Qingchuan,Li, Mingna,Sun, Yan,Liu, Fengqi. 2016

[7]Research advances in microneme protein 3 of Toxoplasma gondii. Wang, Yanhua,Yin, Hong. 2015

[8]Nine facultative endosymbionts in aphids. A review. Hatt, Severin,He, Kanglai,Chen, Julian,Wang, Zhenying,Guo, Jianqing,Hatt, Severin,Francis, Frederic,Guo, Jianqing,Hatt, Severin. 2017

[9]Molecular characterization and expression profile of nanos in Schistosoma japonicum and its influence on the expression several mammalian stem cell factors. Giri, Bikash Ranjan,Du, Xiaoli,Xia, Tianqi,Chen, Yongjun,Li, Hao,Cheng, Guofeng.

[10]FEEDING ON A BEGOMOVIRUS-INFECTED PLANT ENHANCES FECUNDITY VIA INCREASED EXPRESSION OF AN INSULIN-LIKE PEPTIDE IN THE WHITEFLY, MEAM1. Cheng, Lu,Ye, Gong-Yin,Fang, Qi,Guo, Jian-Yang.

[11]Current knowledge of detoxification mechanisms of xenobiotic in honey bees. Gong, Youhui,Diao, Qingyun.

[12]Structure and function of seed storage proteins in faba bean (Vicia faba L.). Liu, Yujiao,Wu, Xuexia,Hou, Wanwei,Li, Ping,Sha, Weichao,Tian, Yingying. 2017

[13]The silkworm GSTe4 is sensitive to phoxim and protects HEK293 cells against UV-induced cell apoptosis. Liu, J.,Zhang, C. D.,Li, Y. F.,Liu, T. H.,Wang, L.,Lu, C.,Pan, M. H.,Liu, J.,Zhang, C. D.,Yu, Q. Y.,Zhang, Y. H.,Lu, C.,Pan, M. H..

[14]Chrysopa septempunctata (Neuroptera: Chrysopidae) Vitellogenin Functions Through Effects on Egg Production and Hatching. Liu, C.,Mao, J.,Zeng, F.,Liu, C..

[15]BIOLOGICAL FUNCTIONS OF microRNAs. Huang, Yong,Shen, Xing Jia,Zhao, Qiao Ling,Shen, Xing Jia,Zhao, Qiao Ling,Zou, Quan.

[16]Biological functions of microRNAs: a review. Huang, Yong,Shen, Xing Jia,Wang, Sheng Peng,Tang, Shun Ming,Zhang, Guo Zheng,Zou, Quan,Huang, Yong,Shen, Xing Jia,Wang, Sheng Peng,Tang, Shun Ming,Zhang, Guo Zheng.

[17]Drought stress impact on leaf proteome variations of faba bean (Vicia faba L.) in the Qinghai-Tibet Plateau of China. Li, Ping,Wu, Xuexia,Liu, Yujiao,Li, Ping,Liu, Yujiao,Zhang, Yanxia,Li, Ping,Liu, Yujiao. 2018

[18]Functional analysis of a viroid RNA motif mediating cell-to-cell movement in Nicotiana benthamiana. Wang, Meng,Jiang, Dongmei,Li, Shifang,Jiang, Dongmei.

[19]Analysis of the diversity and function of the alleles of the rice blast resistance genes Piz-t, Pita and Pik in 24 rice cultivars. Wang Yan,Wang Xiao-xi,Liu Zhi-heng,Wang Yan,Zhao Jia-ming,Zhang Li-xia,Wang Ping,Wang Hui,Zheng Wen-jing,Wang Shi-wei. 2016

[20]Comparative morphology of the distal segments of Malpighian tubules in cicadas and spittlebugs, with reference to their functions and evolutionary indications to Cicadomorpha (Hemiptera: Auchenorrhyncha). Li, Qinglong,Zhong, Haiying,Zhang, Yalin,Wei, Cong,Zhong, Haiying.

作者其他论文 更多>>

微信小程序