Genotype I African swine fever viruses emerged in domestic pigs in China and caused chronic infection

文献类型： 外文期刊

第一作者： Sun, Encheng

作者： Sun, Encheng;Huang, Lianyu;Zhang, Xianfeng;Zhang, Jiwen;Shen, Dongdong;Zhang, Zhenjiang;Wang, Zilong;Huo, Hong;Wang, Wenqing;Huangfu, Haoyue;Wang, Wan;Li, Fang;Liu, Renqiang;Sun, Jianhong;Tian, Zhijun;Xia, Wei;Guan, Yuntao;He, Xijun;Zhu, Yuanmao;Zhao, Dongming;Bu, Zhigao

作者机构：

关键词： African swine fever virus; genotype I; virulence; pig; China

期刊名称：EMERGING MICROBES & INFECTIONS （ 影响因子：7.163； 五年影响因子：7.329 ）

ISSN：

年卷期： 2021 年 10 卷 1 期

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收录情况： SCI

摘要： The Georgia-07-like genotype II African swine fever virus (ASFV) with high virulence has been prevalent in China since 2018. Here, we report that genotype I ASFVs have now also emerged in China. Two non-haemadsorbing genotype I ASFVs, HeN/ZZ-P1/21 and SD/DY-I/21, were isolated from pig farms in Henan and Shandong province, respectively. Phylogenetic analysis of the whole genome sequences suggested that both isolates share high similarity with NH/P68 and OURT88/3, two genotype I ASFVs isolated in Portugal in the last century. Animal challenge testing revealed that SD/DY-I/21 shows low virulence and efficient transmissibility in pigs, and causes mild onset of infection and chronic disease. SD/DY-I/21 was found to cause necrotic skin lesions and joint swelling. The emergence of genotype I ASFVs will present more problems and challenges for the control and prevention of African swine fever in China.

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