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Co-exposure to sodium hypochlorite and cadmium induced locomotor behavior disorder by influencing neurotransmitter secretion and cardiac function in larval zebrafish

文献类型： 外文期刊

作者： Ma, Lingyan 1 ; Yang, Hua 1 ; Xiao, Xingning 1 ; Chen, Qu 1 ; Lv, Wentao 1 ; Xu, Ting 2 ; Jin, Yuanxiang 2 ; Wang, Wen 1 ; Xiao, Yingping 1 ;

作者机构： 1.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou 310021, Peoples R China

2.Zhejiang Univ Technol, Coll Biotechnol & Bioengn, Hangzhou 310032, Peoples R China

关键词： Sodium hypochlorite; Cadmium; Zebrafish larvae; Oxidative stress; Neurotransmitters; Myocardial contraction

期刊名称：ENVIRONMENTAL POLLUTION （ 影响因子：7.6； 五年影响因子：8.3 ）

ISSN： 0269-7491

年卷期： 2024 年 342 卷

页码：

收录情况： SCI

摘要： Sodium hypochlorite (NaClO) and cadmium (Cd) are widely co-occurring in natural aquatic environment; however, no study has been conducted on effects of their combined exposure on aquatic organisms. To assess effects of exposure to NaClO and Cd in zebrafish larvae, we designed six treatment groups, as follows: control group, NaClO group (300 mu g/L), 1/100 Cd group (48 mu g/L), 1/30 Cd group (160 mu g/L), NaClO+1/100 Cd group, and NaClO+1/30 Cd group analyzed behavior, neurological function and cardiac function. Results revealed that exposure to 1/30 Cd and NaClO+1/30 Cd caused abnormal embryonic development in larvae by altering body morphology and physiological indicators. Combined exposure to NaClO and 1/30 Cd affected the free-swimming activity and behavior of larvae in response to light-dark transition stimuli. Moreover, exposure to 1/30 Cd or NaClO+1/30 Cd resulted in a significant increase in tyrosine hydroxylase and acetylcholinesterase activities, as well as significant changes of various neurotransmitters. Lastly, exposure to 1/30 Cd or NaClO+1/30 Cd influenced the transcription of cardiac myosin-related genes and disturbed the myocardial contractile function. Altogether, our results suggested that combined exposure to NaClO and Cd induced oxidative damage in larvae, resulting in detrimental effects on nervous system and cardiac function, thus altering their swimming behavior.

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