Plant-derived exosome-like nanoparticles - from Laboratory to factory, a landscape of application, challenges and prospects
文献类型： 外文期刊
作者： Wei, Chaozhi 1 ; Zhang, Mengyu 1 ; Cheng, Jintao 1 ; Tian, Jinzhong 1 ; Yang, Guiling 1 ; Jin, Yuanxiang 1 ;
作者机构： 1.Xianghu Lab, Biomfg Res Inst, Hangzhou, Peoples R China
2.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, Inst Agroprod Safety & Nutr, Lab Hangzhou Risk Assessment Agr Prod,Minist Agr, Hangzhou 310021, Peoples R China
3.Zhejiang Univ Technol, Coll Biotechnol & Bioengn, Hangzhou, Peoples R China
关键词： Drug delivery activities; extracellular vesicles; isolation techniques; plant-derived exosome-like nanoparticles; therapeutic activities
期刊名称：CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION （ 影响因子：7.3； 五年影响因子：10.3 ）
ISSN： 1040-8398
年卷期： 2024 年
页码：
收录情况： SCI
摘要： Recent decades have witnessed substantial interest in extracellular vesicles (EVs) due to their crucial role in intercellular communication across various biological processes. Among these, plant-derived exosome-like Nanoparticles (ELNs) have rapidly gained recognition as highly promising candidates. ELNs, characterized by diverse sources, cost-effective production, and straightforward isolation, present a viable option for preventing and treating numerous diseases. Furthermore, ELNs hold significant potential as carriers for natural or engineered drugs, enhancing their attractiveness and drawing considerable attention in science and medicine. However, translating ELNs into clinical applications poses several challenges. This study explores these challenges and offers critical insights into potential research directions. Additionally, it provides a forward-looking analysis of the industrial prospects for ELNs. With their broad applications and remarkable potential, ELNs stand at the forefront of biomedical innovation, poised to revolutionize disease management and drug delivery paradigms in the coming years. Graphical Abstract
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