文献类型： 外文期刊

作者： Yang, Mengxue ¹ ; Wang, Yihan ¹ ; Yang, Guiling ² ; Wang, Yanhua ³ ; Liu, Fengquan ⁴ ; Chen, Chen ¹ ;

作者机构： 1.Shandong Univ, Cheeloo Coll Med, Sch Publ Hlth, Jinan 250012, Peoples R China

2.Xianghu Lab, Hangzhou 311231, Peoples R China

3.Zhejiang Acad Agr Sci, Inst Qual & Stand Agroprod, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou 310021, Peoples R China

4.Guizhou Univ, Coll Agr, Dept Plant Pathol, Key Lab Agr Microbiol, Guiyang 550025, Peoples R China

关键词： Multiple pesticide residues; Dietary exposure; Cumulative risk assessment; Regulation; Maximum residue limits (MRLs); Mixture assessment methods

期刊名称：TRENDS IN FOOD SCIENCE & TECHNOLOGY （ 影响因子：15.3； 五年影响因子：16.6 ）

ISSN： 0924-2244

年卷期： 2024 年 144 卷

页码：

收录情况： SCI

摘要： Background: The widespread application of pesticides in agricultural production often leads to the occurrence of multiple pesticide residues in food, which have the potential to accumulate within the human body and cause cumulative health risks. In order to address this matter, regulatory measures have been established to ensure the incorporation of cumulative effects in the risk assessment for pesticides. Scope and approach: This review provides an in-depth look at the current status of cumulative risk assessment (CRA) of multiple pesticide residues in food, highlighting recent advances in regulations, methods for grouping pesticides, characterization of the cumulative hazard and risk, and the suitability of dose-addition assumptions, as well as data requirements. In addition, case studies of CRA for pesticide residues that have been conducted globally are also collected, which effectively assist in assessing the actual cumulative exposure risks associated with pesticide residues and informing the establishment of maximum residue limits (MRLs) in food. Further, the development of new assessment methods is summarized, including the incorporation of mixture assessment factors (MAF), adverse outcome pathway (AOP) networks, as well as the methodologies for prioritizing the main drivers of the cumulative risk and grouping pesticides based on their interactions related to toxicokinetic interference. Key findings and conclusions: This review emphasizes the importance of regularly conducting retrospective and prospective cumulative risk assessments to incorporate changes in exposure patterns and updates to the cumulative assessment group (CAG). Global research has shown that significant health risks from cumulative pesticide exposure arise primarily under highly conservative assumptions, with a limited set of pesticides primarily affecting CRA outcomes. This finding suggests that future research focus on specific pesticide/commodity combinations and their cumulative effects. Finally, it is highlighted that incorporating the new assessment methods will allow for more accurate information for risk assessment, informing pesticide authorizations and regulatory limit settings.