Novel mechanism by which extracellular vesicles derived from Lactobacillus murinus alleviates deoxynivalenol-induced intestinal barrier disruption
文献类型： 外文期刊
作者： Fan, Jinping 1 ; Zhang, Yuhan 1 ; Zuo, Minyu 1 ; Ding, Shixuan 1 ; Li, Jingjing 1 ; Feng, Shengkai 1 ; Xiao, Yingping 2 ; Tao, Shiyu 1 ;
作者机构： 1.Huazhong Agr Univ, Coll Anim Sci & Technol, Wuhan 430070, Peoples R China
2.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou 310021, Peoples R China
关键词： Deoxynivalenol; Lactobacillus murinus; Extracellular vesicles; Macrophage; Gut barrier
期刊名称：ENVIRONMENT INTERNATIONAL （ 影响因子：10.3； 五年影响因子：11.1 ）
ISSN： 0160-4120
年卷期： 2024 年 185 卷
页码：
收录情况： SCI
摘要： Deoxynivalenol (DON) is a common environmental pollutant that poses a serious health risk to humans worldwide. This study was aim to explore whether gut microbiota is involved in DON-induced intestinal toxicity as well as to reveal effect of probiotics derived from gut microbiota in protecting intestinal barrier and to elucidate mechanism. We found that DON caused disturbed gut microbiota, particularly Lactobacillus murinus (L. murinus) deficiency. DON enhanced M1 macrophage polarization and decreased tight junction protein expression. Microbiota transplantation experiments showed that transfer of DON-disrupted microbiota to healthy mice resulted in delivery of DON-induced intestinal toxicity. Besides, DON lost its damaging effect on macrophage and intestinal barrier in antibiotic-treated mice. Further intervention experiments revealed that L. murinus induce macrophage conversion from M1 to M2 phenotype through secreted extracellular vesicles (EVs) to alleviate DON-induced intestinal barrier disruption. Mechanistically, EVs activate TLR2 to promote M2 macrophage polarization and release IL-10, which in turn enhances intestinal barrier function. Upon successful translation of its efficacy into clinical practice, EVs created from L. murinus could be a novel possible treatment strategy for DON-induced gut disease.
- 相关文献
作者其他论文 更多>>
-
Linking growth performance and carcass traits with enterotypes in Muscovy ducks
作者：Fan, Qian;Xu, Yini;Yang, Caimei;Lyu, Wentao;Fan, Qian;Xu, Yini;Xiao, Yingping;Lyu, Wentao;Yang, Hua
关键词：Enterotype; Ileal Microbiota; Muscovy Duck; 16S rRNA Gene Sequencing
-
Distribution and safety evaluation of deoxynivalenol and its derivatives throughout the wheat product processing chain
作者：Ji, Xiaofeng;He, Yeyu;Xiao, Yingping;Yang, Hua;Wang, Xiaodan;Liang, Ying;Yang, Weikang;Guo, Cheng;Xiong, Lina;Zhang, Jiahong
关键词：Mycotoxins; Wheat; Food chain; Processing; Food safety; Regulation
-
A Bioinspired Photosensitizer Performs Tumor Thermoresistance Reversion to Optimize the Atraumatic Mild-Hyperthermia Photothermal Therapy for Breast Cancer
作者：Li, Jie;Yang, Die;Yuan, Yan;Han, Xiao;Yue, Weiqing;Jiang, Jian;Fang, Zhijie;Lu, Xiaomei;Huang, Wei;Li, Jie;Yang, Die;Yuan, Yan;Han, Xiao;Yue, Weiqing;Jiang, Jian;Fang, Zhijie;Lu, Xiaomei;Huang, Wei;Li, Jie;Yang, Die;Yuan, Yan;Han, Xiao;Yue, Weiqing;Jiang, Jian;Fang, Zhijie;Lu, Xiaomei;Huang, Wei;Lyu, Wentao;Xiao, Yingping;Wang, Wen;Lu, Xiaomei;Huang, Wei;Huang, Wei
关键词：atraumatic breast cancer therapy; bioinspired photosensitizer; mild-hyerthermia photothermal therapy; photodynamic effect; tumor thermoresistance
-
Comprehensive identification and risk assessment of regulated and emerging mycotoxins in infant foods and related raw materials and risk management advice: A case study of an infant food company in China
作者：Ji, Xiaofeng;Xiao, Yingping;Wei, Wang;Lyu, Wentao;Wang, Xiaoli;Yang, Hua;Yang, Weikang;Yang, Hua
关键词：Infant food; Wheat; Cereals; Mycotoxins; Food safety; Risk management
-
Co-exposure to sodium hypochlorite and cadmium induced locomotor behavior disorder by influencing neurotransmitter secretion and cardiac function in larval zebrafish
作者：Ma, Lingyan;Yang, Hua;Xiao, Xingning;Chen, Qu;Lv, Wentao;Wang, Wen;Xiao, Yingping;Xu, Ting;Jin, Yuanxiang
关键词：Sodium hypochlorite; Cadmium; Zebrafish larvae; Oxidative stress; Neurotransmitters; Myocardial contraction
-
Insights into microbial contamination and antibiotic resistome traits in pork wholesale market: An evaluation of the disinfection effect of sodium hypochlorite
作者：Xiao, Xingning;He, Miao;Ma, Lingyan;Lv, Wentao;Yang, Hua;Xiao, Yingping;Wang, Wen;He, Miao;Huang, Kang;Li, Yanbin;Zou, Likou;Xiao, Yingping;Wang, Wen;Zou, Likou
关键词：Pork wholesale market; NaClO; Chlorine tolerance; Metagenomics; Antimicrobial resistance
-
Tracking investigation of archaeal composition and methanogenesis function from parental to offspring pigs
作者：Chen, Qu;Lyu, Wentao;Pan, Chenglin;Ma, Lingyan;Sun, Yue;Yang, Hua;Wang, Wen;Xiao, Yingping
关键词：Swine gut archaea; Metagenomics; Methanogenesis function; Longitudinal study
