您好，欢迎访问中国水产科学研究院 机构知识库！
中国水产科学研究院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Concentration-dependent effect of norfloxacin on iron toxicity in the intestine of large yellow croaker Larimichthys crocea (Richardson, 1846)

文献类型： 外文期刊

作者： Zeng, Lin 1 ; Wang, Yong-Hong 1 ; Ai, Chun-Xiang 2 ; Liu, Bin 3 ; Yu, Min-Hui 2 ; Zhang, Hui 5 ; Li, Fei 6 ;

作者机构： 1.Bengbu Univ, Coll Food & Biol Engn, Bengbu, Peoples R China

2.Xiamen Univ, Coll Ocean & Earth Sci, Xiamen, Peoples R China

3.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, State Key Lab Mariculture Biobreeding & Sustainabl, Qingdao, Peoples R China

4.Qingdao Marine Sci & Technol Ctr, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao, Peoples R China

5.Zhejiang Ocean Univ, Natl Engn Res Ctr Marine Facil Aquaculture, Zhoushan, Peoples R China

6.Tangshan Maritime Inst, Coll Fishery Econ, Tangshan, Peoples R China

关键词： iron exposure; norfloxacin; NF-kappa B; HSP; Larimichthys crocea

期刊名称：FRONTIERS IN MARINE SCIENCE （ 影响因子：3.0； 五年影响因子：3.8 ）

ISSN：

年卷期： 2025 年 11 卷

页码：

收录情况： SCI

摘要： This study explores the effects of norfloxacin (NOR) on oxidative damage, iron (Fe) transport, energy metabolism, and immunotoxicity in the intestine of large yellow croaker under Fe stress. The fish were subjected to Fe (180 mu g/L), low-dose NOR (1.8 mu g/L, LNOR), high-dose NOR (180 mu g/L, HNOR), Fe plus LNOR, and Fe plus HNOR for 60 days. These results demonstrated that Fe alone exposure increased malondialdehyde (MDA), protein carboxylation (PC), and mortality rate, and impaired intestinal tissue, which was related to the increment of Fe accumulation. Compared to Fe alone exposure, Fe plus LNOR exposure decreased MDA, PC, and mortality rate, and alleviated intestinal malformations by improving Fe transport, energy metabolism, anti-inflammatory response, and protein folding protective effect, and reducing pro-inflammatory response, indicating that LNOR had an antagonistic effect on Fe toxicity. Compared to Fe alone exposure, Fe plus HNOR exposure elevated MDA, PC, and mortality rate, and deteriorated intestinal malformations by inhibiting Fe excretion, energy metabolism, anti-inflammatory response, and protein folding protective effect, and enhancing pro-inflammatory response, indicating a synergetic effect between HNOR and Fe stress. These findings suggested that NOR had a dose-dependent effect on Fe-toxicity to large yellow croaker, which contributes to revealing the molecular mechanisms behind their interaction and its ecological implications.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：中国水产科学研究院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台