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Establishment of an Animal Model Scheme of Strongyloides stercoralis-Infected Meriones meridianus

文献类型： 外文期刊

作者： Zhou, Huan 1 ; Hu, Jinyang 1 ; Zhou, Taoxun 1 ; Zhang, Ying 1 ; Qin, Peixi 1 ; Zhang, Biying 1 ; Wang, Rui 3 ; Luo, Xiaoping 4 ; Hu, Min 1 ;

作者机构： 1.Huazhong Agr Univ, Coll Vet Med, Natl Key Lab Agr Microbiol, Wuhan 430070, Peoples R China

2.Henan Univ, Sch Life Sci, Kaifeng 475004, Peoples R China

3.Inner Mongolia Agr Univ, Coll Vet Med, Hohhot 010030, Peoples R China

4.Inner Mongolia Acad Agr & Anim Husb Sci, Hohhot 010030, Peoples R China

关键词： Strongyloides stercoralis; Meriones meridianus; animal model

期刊名称：PATHOGENS （ 影响因子：3.7； 五年影响因子：3.7 ）

ISSN：

年卷期： 2023 年 12 卷 11 期

页码：

收录情况： SCI

摘要： Studying parasitic nematodes, which generate a massive hazard to animal health, is more difficult than studying free-living nematodes as appropriate animal models are essential, and the relationship between parasites and hosts is extremely complex. Strongyloides stercoralis is an intestinal nematode parasite that mainly infects dogs, humans and other primates. Currently, S. stercoralis worms needed for research mainly rely on their natural host, the dog. This study explored a method of using Meriones meridianus as a model for S. stercoralis. The immunosuppressed M. meridianus were infected with S. stercoralis subcutaneously, and post-parasitic, first-stage larvae (PP L1) were detected in the faeces, with more larvae in female gerbils. In addition, parasitic females (PFs), third-stage larvae (L3s) and rhabditiform larvae were found primarily in the small intestines and lungs of infected gerbils. The PFs and auto-infective third-stage larvae (aL3s) obtained from M. meridianus are morphologically identical to those obtained from beagles and Meriones unguiculatus. Moreover, the infection of S. stercoralis caused changes to biochemical indicators in the serum and in the physiology of M. meridianus. The results demonstrated that M. meridianus can be infected by S. stercoralis, and this model provides a great tool for exploring the biological processes of this parasite and its interaction with the host.

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