Molecular mechanism of Yersinia ruckeri Flagellin C (FliC) induced intestinal inflammation in channel catfish ( Ictalurus punctatus)
文献类型： 外文期刊
作者： Yang, Yibin 1 ; He, Hao 1 ; Huang, Yucong 2 ; Ai, Xiaohui 1 ; Zhu, Xia 1 ; Yin, Fei 3 ; Xu, Jingen 4 ; Chen, Yuhua 5 ;
作者机构： 1.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Wuhan 430223, Peoples R China
2.Guangdong Ocean Univ, Coll Fisheries, Guangdong Prov Key Lab Aquat Anim Dis Control & Hl, Zhanjiang 524088, Peoples R China
3.Ningbo Univ, Minist Educ, Key Lab Aquacultural Biotechnol, Ningbo 315211, Peoples R China
4.Jilin Acad Agr Sci, Jiujiang 332005, Peoples R China
5.Wuhan Univ, Zhongnan Hosp, Dept Gastroenterol, Wuhan 430071, Peoples R China
关键词： Channel catfish; Yersinia ruckeri; Virulence; Intestinal inflammation; Molecular mechanism
期刊名称：COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY （ 影响因子：1.8； 五年影响因子：2.1 ）
ISSN： 1096-4959
年卷期： 2025 年 277 卷
页码：
收录情况： SCI
摘要： Yersinia ruckeri is known to cause enteric red mouth disease (ERM) in channel catfish ( Ictalurus punctatus). This study established a model of Y. ruckeri-induced intestinal inflammation in channel catfish. Subsequently, using quantitative polymerase chain reaction (qPCR), gene cloning, recombinant protein expression, protein molecular docking, and tissue pathology techniques, we investigated the role and molecular mechanism of Flagellin C (FliC) from Y. ruckeri in inducing inflammation. The findings indicated that FliC was the main virulence gene in Y. ruckeri responsible for inducing intestinal inflammation. Specifically, FliC bound to the host Toll-like receptor 5 (tlr5), leading to the upregulation of multiple inflammatory factors such as tumor necrosis factor ( tnf )-alpha , interleukin (il)-6, and il-1 beta, and the activation of the nuclear factor-kappaB (NF-kappa B) and JAK-STAT signaling pathways, thereby initiating inflammation. The results were validated through experiments conducted both in cellular models and in vivo. In summary, this study identified FliC as a virulence gene in Y. ruckeri infection of channel catfish and elucidated its role in inducing intestinal inflammation.
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