Population Pharmacokinetics of Enrofloxacin in Micropterus salmoides Based on a Nonlinear Mixed Effect Model After Intravenous and Oral Administration
文献类型： 外文期刊
作者： Xu, Ning 1 ; Zhou, Shun 1 ; Dong, Jing 1 ; Li, Jiangtao 1 ; Ding, Yongzhen 3 ; Ai, Xiaohui 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Wuhan 430223, Peoples R China
2.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Wuxi 214081, Peoples R China
3.Minist Agr & Rural Affairs, Agroenvironm Protect Inst, Tianjin 300191, Peoples R China
关键词： enrofloxacin; population pharmacokinetics; statistical approaches; largemouth bass; body weight
期刊名称：ANIMALS （ 影响因子：2.7； 五年影响因子：3.2 ）
ISSN： 2076-2615
年卷期： 2025 年 15 卷 10 期
页码：
收录情况： SCI
摘要： This study aimed to investigate the PPK of EF in largemouth bass after oral and intravenous administration based on a nonlinear mixed effect model. Samples were collected using the sparse sampling method at pre-designed time points determined by high-performance liquid chromatography with a fluorescent detector. The initial PK parameters were estimated by reference search and the calculation of a na & iuml;ve pooled approach. The covariate model included a variation in body weight. The oral dose data were best fitted by a one-compartment model. The injection dose data were best fitted by a two-compartment model. The results demonstrated that body weight had no marked effect on the parameters of PPK. Finally, the bioavailability was calculated to be 12.24%. The area under the concentration-time curve/minimum inhibitory concentration was estimated to be >= 408.16, indicating that EF at 20 mg/kg has high effectiveness for aquatic pathogens.
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