The Preparation of Golgi Apparatus-Targeted Polymer Dots Encapsulated with Carbon Nanodots of Bright Near-Infrared Fluorescence for Long-Term Bioimaging
文献类型： 外文期刊
作者： Lu, Yiping 1 ; Song, Wei 3 ; Tang, Zhiquan 1 ; Shi, Wenru 1 ; Gao, Shumei 1 ; Wu, Jun 2 ; Wang, Yuan 1 ; Pan, Hu 1 ; Wang, Yangang 1 ; Huang, Hong 1 ;
作者机构： 1.Jiaxing Univ, Coll Biol Chem Sci & Engn, Jiaxing 314001, Peoples R China
2.Jiaxing Nanhu Univ, Coll Adv Mat Engn, Jiaxing 314001, Peoples R China
3.Shanghai Acad Agr Sci, Inst Agrifood Stand & Testing Technol, Shanghai 201403, Peoples R China
关键词： Golgi apparatus; carbon nanodots; polymer dots; near-infrared fluorescence; high photostability; long term
期刊名称：MOLECULES （ 影响因子：4.6； 五年影响因子：4.9 ）
ISSN：
年卷期： 2023 年 28 卷 17 期
页码：
收录情况： SCI
摘要： As a vital organelle in eukaryotic cells, the Golgi apparatus is responsible for processing and transporting proteins in cells. Precisely monitoring the status of the Golgi apparatus with targeted fluorescence imaging technology is of enormous importance but remains a dramatically challenging task. In this study, we demonstrate the construction of the first Golgi apparatus-targeted near-infrared (NIR) fluorescent nanoprobe, termed Golgi-Pdots. As a starting point of our investigation, hydrophobic carbon nanodots (CNDs) with bright NIR fluorescence at 674 nm (fluorescence quantum yield: 12.18%), a narrow emission band of 23 nm, and excellent stability were easily prepared from Magnolia Denudata flowers using an ultrasonic method. Incorporating the CNDs into a polymer matrix modified with Golgi-targeting molecules allowed for the production of the water-soluble Golgi-Pdots, which showed high colloidal stability and similar optical properties compared with pristine CNDs. Further studies revealed that the Golgi-Pdots showed good biocompatibility and Golgi apparatus-targeting capability. Based on these fascinating merits, utilizing Golgi-Pdots for the long-term tracking of the Golgi apparatus inside live cells was immensely successful.
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