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Double-faced role of Bcl-2-associated athanogene 7 in plant-Phytophthora interaction

文献类型： 外文期刊

作者： Zhou, Yang 1 ; Yang, Kun 1 ; Cheng, Ming 1 ; Cheng, Yang 1 ; Li, Yurong 2 ; Ai, Gan 1 ; Bai, Tian 1 ; Xu, Ruofei 1 ; Duan, W 1 ;

作者机构： 1.Nanjing Agr Univ, Key Lab Plant Immun, Coll Plant Protect, Nanjing 210095, Peoples R China

2.Corteva Agrisci, Johnston, IA 50131 USA

3.Texas A&M Univ, Inst Plant Genom & Biotechnol, College Stn, TX 77843 USA

4.Texas A&M Univ, Dept Plant Pathol & Microbiol, College Stn, TX 77843 USA

5.Washington State Univ, Dept Crop & Soil Sci, Pullman, WA 99164 USA

6.Guangdong Acad Agr Sci, Crops Res Inst, Guangdong Prov Key Lab Crop Genet Improvement, Guangzhou 510640, Guangdong, Peoples R China

关键词： BAG7; BiP; effector; ER stress-mediated immunity; plant-Phytophthora interaction; susceptibility factor

期刊名称：JOURNAL OF EXPERIMENTAL BOTANY （ 影响因子：6.992； 五年影响因子：7.86 ）

ISSN： 0022-0957

年卷期： 2021 年 72 卷 15 期

页码：

收录情况： SCI

摘要： Due to their sessile nature, plants must respond to various environmental assaults in a coordinated manner. The endoplasmic reticulum is a central hub for plant responses to various stresses. We previously showed that Phytophthora utilizes effector PsAvh262-mediated binding immunoglobulin protein (BiP) accumulation for suppressing endoplasmic reticulum stress-triggered cell death. As a BiP binding partner, Bcl-2-associated athanogene 7 (BAG7) plays a crucial role in the maintenance of the unfolded protein response, but little is known about its role in plant immunity. In this work, we reveal a double-faced role of BAG7 in Arabidopsis-Phytophthora interaction in which it regulates endoplasmic reticulum stress-mediated immunity oppositely in different cellular compartments. In detail, it acts as a susceptibility factor in the endoplasmic reticulum, but plays a resistance role in the nucleus against Phytophthora. Phytophthora infection triggers the endoplasmic reticulum-to-nucleus translocation of BAG7, the same as abiotic heat stress; however, this process can be prevented by PsAvh262-mediated BiP accumulation. Moreover, the immunoglobulin/albumin-binding domain in PsAvh262 is essential for both pathogen virulence and BiP accumulation. Taken together, our study uncovers a double-faced role of BAG7; Phytophthora advances its colonization in planta by utilizing an effector to detain BAG7 in the endoplasmic reticulum.

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