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Effects of Lipopolysaccharide and Deoxynivalenol on the Survival, Antioxidant and Immune Response, and Histopathology of Crayfish (Procambarus clarkii)

文献类型： 外文期刊

作者： Wen, Zhengrong 1 ; Xu, Xiaoli 2 ; Xiang, Dan 1 ; Xu, Junfeng 2 ; Yang, Qiufeng 1 ; Wang, Xiaofu 2 ; Liu, Jiashou 3 ; Luo, Mingzhong 1 ; Wei, Wei 2 ;

作者机构： 1.Yangtze Univ, Engn Res Ctr Ecol & Agr Use Wetland, Minist Educ, Hubei Key Lab Waterlogging Disaster & Agr Use Wetl, Jingzhou 434025, Peoples R China

2.Zhejiang Acad Agr Sci, State Key Lab Managing Biot & Chem Threats Qual &, Key Lab Traceabil Agr Genet Modified Organisms, Minist Agr & Rural Affairs, Hangzhou 310021, Peoples R China

3.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China

关键词： crayfish; deoxynivalenol; lipopolysaccharide; survival; antioxidant and immune response; histopathological changes

期刊名称：TOXINS （ 影响因子：4.2； 五年影响因子：4.7 ）

ISSN：

年卷期： 2023 年 15 卷 8 期

页码：

收录情况： SCI

摘要： Bacterial lipopolysaccharide (LPS) in the aquatic environment has been reported to cause diseases in red swamp crayfish (Procambarus clarkii). In addition, deoxynivalenol (DON) is one of the primary mycotoxins found in aquaculture. However, the potential synergistic toxic effects of LPS and DON on crayfish are yet to be fully elucidated. In this study, crayfish were exposed to LPS (1 mg kg-1), DON (3 mg kg(-1)), and their combination (1 mg kg(-1) LPS + 3 mg kg(-1) DON, L+D) for a duration of six days. Co-exposure to LPS and DON exhibited the lowest survival rate compared to the control or individual treatments with LPS or DON alone. In the initial stage of the experiment, the combined treatment of LPS and DON showed a more pronounced up-regulation of antioxidant and immune-related enzymes in the sera compared to the other treatment groups, with a fold change ranging from 1.3 to 15. In addition, the (L+D) treatment group showed a down-regulation of immune-related genes, as well as Toll pathway-related genes in the hepatopancreas compared to LPS or DON. Moreover, the (L+D) treatment group demonstrated a 100% incidence of histopathological changes in the hepatopancreas, which were significantly more severe compared to the other three groups. In conclusion, our study provides physiological and histopathological evidence that the co-exposure to LPS and DON exerted synergistic toxic effects on crayfish. The observed effects could potentially hinder the development of the crayfish aquaculture industry in China.

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