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High-content tailoring strategy to improve the multifunctionality of functional nucleic acids

文献类型： 外文期刊

作者： Chen, Keren 1 ; Zhu, Longjiao 1 ; Li, Jie 2 ; Zhang, Yangzi 1 ; Yu, Yongxia 1 ; Wang, Xiaofu 3 ; Wei, Wei 3 ; Huang, Kunlun 2 ; Xu, Wentao 1 ;

作者机构： 1.China Agr Univ, Dept Nutr & Hlth, Food Lab Zhongyuan, Key Lab Precis Nutr & Food Qual, Beijing 100193, Peoples R China

2.China Agr Univ, Coll Food Sci & Nutr Engn, Beijing Lab Food Qual & Safety, Key Lab Safety Assessment Genet Modified Organism, Beijing 100083, Peoples R China

3.Zhejiang Acad Agr Sci, Minist Agr & Rural Affairs, Key Lab Traceabil Agr Genetically Modified Organis, Hangzhou 310021, Peoples R China

关键词： Functional nucleic acids; Tailoring strategies; High-content; Rational design; Multifunctionality; Affinity; Aptamer

期刊名称：BIOSENSORS & BIOELECTRONICS （ 影响因子：10.7； 五年影响因子：9.9 ）

ISSN： 0956-5663

年卷期： 2024 年 261 卷

页码：

收录情况： SCI

摘要： Functional nucleic acids (FNAs) have attracted increasing attention in recent years due to their diverse physiological functions. The understanding of their conformational recognition mechanisms has advanced through nucleic acid tailoring strategies and sequence optimization. With the development of the FNA tailoring techniques, they have become a methodological guide for nucleic acid repurposing. Therefore, it is necessary to systematize the relationship between FNA tailoring strategies and the development of nucleic acid multifunctionality. This review systematically categorizes eight types of FNA multifunctionality, and introduces the traditional FNA tailoring strategy from five aspects, including deletion, substitution, splitting, fusion and elongation. Based on the current state of FNA modification, a new generation of FNA tailoring strategy, called the high-content tailoring strategy, was unprecedentedly proposed to improve FNA multifunctionality. In addition, the multiple applications of rational tailoring-driven FNA performance enhancement in various fields were comprehensively summarized. The limitations and potential of FNA tailoring and repurposing in the future are also explored in this review. In summary, this review introduces a novel tailoring theory, systematically summarizes eight FNA performance enhancements, and provides a systematic overview of tailoring applications across all categories of FNAs. The high-content tailoring strategy is expected to expand the application scenarios of FNAs in biosensing, biomedicine and materials science, thus promoting the synergistic development of various fields.

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