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Microbiota-Gut-Brain Axis in Age-Related Neurodegenerative Diseases

文献类型： 外文期刊

作者： Nie, Tong 1 ; You, Li 2 ; Tang, Fang 3 ; Duan, Yanhui 4 ; Nepovimova, Eugenie 5 ; Kuca, Kamil 5 ; Wu, Qinghua 1 ; Wei, Wei 7 ;

作者机构： 1.Yangtze Univ, Coll Life Sci, Jingzhou 434025, Peoples R China

2.Chongqing Coll Int Business & Econ, Coll Phys Educ & Hlth, Chongqing 401520, Peoples R China

3.Yangtze Univ, Coll Humanities & New Media, Jingzhou 434025, Peoples R China

4.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China

5.Univ Hradec Kralove, Fac Sci, Dept Chem, Hradec Kralove 50003, Czech Republic

6.Univ Hosp Hradec Kralove, Biomed Res Ctr, Hradec Kralove 50005, Czech Republic

7.Zhejiang Acad Agr Sci, State Key Lab Managing Biot & Chem Threats Qual &, Key Lab Traceabil Agr Genet Modified Organisms, Minist Agr & Rural Affairs, Hangzhou 310021, Peoples R China

关键词： Neurodegenerative diseases; gut microbiota; blood-brain barrier; microbiota-gut-brain axis; therapy; dietary adaptations

期刊名称：CURRENT NEUROPHARMACOLOGY （ 影响因子：5.3； 五年影响因子：7.4 ）

ISSN： 1570-159X

年卷期： 2025 年 23 卷 5 期

页码：

收录情况： SCI

摘要： Background Age-related neurodegenerative diseases (NDs) pose a formidable challenge to healthcare systems worldwide due to their complex pathogenesis, significant morbidity, and mortality.Scope and Approach This comprehensive review aims to elucidate the central role of the microbiota-gut-brain axis (MGBA) in ND pathogenesis. Specifically, it delves into the perturbations within the gut microbiota and its metabolomic landscape, as well as the structural and functional transformations of the gastrointestinal and blood-brain barrier interfaces in ND patients. Additionally, it provides a comprehensive overview of the recent advancements in medicinal and dietary interventions tailored to modulate the MGBA for ND therapy.Conclusion Accumulating evidence underscores the pivotal role of the gut microbiota in ND pathogenesis through the MGBA. Dysbiosis of the gut microbiota and associated metabolites instigate structural modifications and augmented permeability of both the gastrointestinal barrier and the blood-brain barrier (BBB). These alterations facilitate the transit of microbial molecules from the gut to the brain via neural, endocrine, and immune pathways, potentially contributing to the etiology of NDs. Numerous investigational strategies, encompassing prebiotic and probiotic interventions, pharmaceutical trials, and dietary adaptations, are actively explored to harness the microbiota for ND treatment. This work endeavors to enhance our comprehension of the intricate mechanisms underpinning ND pathogenesis, offering valuable insights for the development of innovative therapeutic modalities targeting these debilitating disorders.

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