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Effects of chronic co-exposure polystyrene nanoplastics and cadmium on liver function in Prussian carp (Carassius gibelio)

文献类型： 外文期刊

作者： Luo, Mingzhong 1 ; Ding, Yilin 1 ; Zeng, Huixin 1 ; Zhong, Yanfei 1 ; Zhang, Haoyu 1 ; Chen, Yuxi 1 ; Xu, Xiaoli 2 ; Wei, Wei 2 ;

作者机构： 1.Yangtze Univ, Coll Anim Sci & Technol, Jingzhou 434025, Peoples R China

2.Zhejiang Acad Agr Sci, Minist Agr & Rural Affairs, State Key Lab Qual & Safety Agroprod, Key Lab Traceabil Agr Genet Modified Organisms, Hangzhou 310021, Peoples R China

关键词： Nanoplastics; Cadmium; Carassius gibelio; Hepatotoxicity; Immune response

期刊名称：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY （ 影响因子：6.1； 五年影响因子：6.4 ）

ISSN： 0147-6513

年卷期： 2025 年 302 卷

页码：

收录情况： SCI

摘要： Nanoplastics (NPs) are tiny plastic particles that arise from the degradation of microplastics. They have an extensive presence in aquatic environments and exert high ecotoxicity in aquatic organisms. In this study, Prussian carp (Carassius gibelio) was used to assess the hepatotoxicity of polystyrene nanoplastics (PS-NPs) and cadmium (Cd) following 21 days of individual and combined exposures. The results showed that co-exposure to PS-NPs and Cd enhanced PS-NPs accumulation in the liver. Compared to their individual effects, simultaneous exposure to PS-NPs and Cd led to more severe histopathological damage to liver tissue and increased liver transaminases activities. Additionally, this co-exposure resulted in decreased superoxide dismutase (SOD) activity, with increased malondialdehyde (MDA) and total antioxidant capacity (T-AOC). Moreover, the transcriptional levels of immune-associated genes were up-regulated. In conclusion, PS-NPs and Cd exhibit synergistic toxic effects on the liver of Prussian carp. These findings offer crucial insights into the combined hepatotoxicity of NPs and heavy metals in aquatic organisms, suggesting potential risks to human health.

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