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Combined exposure to microplastics and copper elicited size-dependent uptake and toxicity responses in red swamp crayfish ( Procambarus clarkia)

文献类型： 外文期刊

作者： Zeng, Huixin 1 ; Zhong, Yanfei 1 ; Wei, Wei 2 ; Luo, Mingzhong 1 ; Xu, Xiaoli 2 ;

作者机构： 1.Yangtze Univ, Coll Anim Sci & Technol, Jingzhou 434025, Peoples R China

2.Zhejiang Acad Agr Sci, State Key Lab Managing Biot & Chem Threats Qual &, Key Lab Traceabil Agr Genet Modified Organisms, Minist Agr & Rural Affairs, Hangzhou 310021, Peoples R China

关键词： Microplastics; Copper; Accumulation; Combined toxicity; Antioxidant enzyme

期刊名称：JOURNAL OF HAZARDOUS MATERIALS （ 影响因子：11.3； 五年影响因子：12.4 ）

ISSN： 0304-3894

年卷期： 2025 年 487 卷

页码：

收录情况： SCI

摘要： In recent years, the toxicity of microplastics (MPs) in combination with heavy metals, particularly the influence of varying microplastic sizes on their toxic effects, has attracted widespread attention. In this study, red swamp crayfish (Procambarus clarkia) were exposed to MPs of two particle sizes (S-MPs: 5 mu m, 1 mg/L; and L-MPs: 100 mu m, 1 mg/L) and Cu (5 mg/L) individually or in combination for 96 h. The accumulation patterns of MPs were as follows: gills > intestines > hepatopancreas > muscles. Moreover, the accumulation pattern of Cu was as follows: intestines > gills > hepatopancreas > muscle. Additionally, S-MPs and L-MPs enhanced Cu accumulation, with the highest levels observed in the S-MPs+Cu-treated group. Histopathological analysis showed that the combined exposure led to greater hepatopancreatic damage. Assessment of antioxidant enzymes showed decreased activities of superoxide dismutase, catalase, and glutathione among the different treatments, except for malondialdehyde, which was elevated compared to the control group. In the S-MPs+Cu-treated group, the expression levels of Cu homeostasis genes (MTF-1, ATP2, Atox1, MT) were significantly lower than those in the Cu treated group. This study provides a valuable reference for studying the combined toxic effects of MPs with varying particle sizes on heavy metals.

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