Lactobacillus plantarum S9 alleviates lipid profile, insulin resistance, and inflammation in high-fat diet-induced metabolic syndrome rats
文献类型： 外文期刊
作者： Zhao, Lei 1 ; Shen, Yunjiao 1 ; Wang, Yunlong 2 ; Wang, Lei 1 ; Zhang, Lin 3 ; Zhao, Zijian 3 ; Li, Shengyu 3 ;
作者机构： 1.Changchun Univ Chinese Med, Sch Pharmaceut Sci, Changchun 130117, Peoples R China
2.Giant Praise JILIN Pharmaceut Co LTD, Changchun 130033, Peoples R China
3.Jilin Acad Agr Sci, Inst Agr Prod Proc Technol, Natl R&D Ctr Milk Proc, Changchun 130033, Peoples R China
期刊名称：SCIENTIFIC REPORTS （ 影响因子：4.996； 五年影响因子：5.516 ）
ISSN： 2045-2322
年卷期： 2022 年 12 卷 1 期
页码：
收录情况： SCI
摘要： Probiotics are considered to play an crucial role in the treatment of high-fat diet (HFD)-induced lipid metabolic diseases, including metabolic syndrome (MS). This study aimed to investigate the effects of Lactobacillus plantarum S9 on MS in HFD-fed rats, and to explore the underlying role of probiotics in the treatment of MS. Sprague-Dawley rats were fed with HFD for 8 weeks, followed by the treatment of L. plantarum S9 for 6 weeks, and The body weight and blood glucose level of rats were detected on time. The results showed that L. plantarum S9 significantly decreased the body weight gain, Lee's index, and liver index. Additionally, L. plantarum S9 reduced the levels of serum lipids and insulin resistance. L. plantarum S9 also decreased the levels of alanine aminotransferase (ALT) and aspartate transaminase (AST) in liver. Moreover, the serum levels of MS-related inflammatory signaling molecules, including lipopolysaccharide (LPS) and tumor necrosis factor-alpha (TNF-alpha), were significantly elevated. Western blot analysis showed that L. plantarum S9 inhibited the activation of nuclear factor-kappa B (NF-kappa B) pathway, decreased the expression level of Toll-like receptor 4 (TLR4), suppressed the activation of inflammatory signaling pathways, and reduced the expression levels of inflammatory factors in HFD-fed rats. Moreover, it further decreased the ratios of p-I kappa B alpha/I kappa B alpha, p-p65/NF-kappa B p65, and p-p38/p38. In summary, L. plantarum S9, as a potential functional strain, prevents or can prevent onset of MS.
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