您好，欢迎访问广东省农业科学院 机构知识库！
广东省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Transcriptome and proteome profile of jejunum in chickens challenged with Salmonella Typhimurium revealed the effects of dietary bilberry anthocyanin on immune function

文献类型： 外文期刊

作者： Zhang, Sheng 1 ; Wang, Qin 1 ; Ye, Jinling 1 ; Fan, Qiuli 1 ; Lin, Xiajing 1 ; Gou, Zhongyong 1 ; Azzam, Mahmoud M. 2 ; Wang, Yibing 1 ; Jiang, Shouqun 1 ;

作者机构： 1.Guangdong Acad Agr Sci, Inst Anim Sci, Minist Agr & Rural Affairs, State Key Lab Livestock & Poultry Breeding,Key Lab, Guangzhou, Guangdong, Peoples R China

2.King Saud Univ, Dept Anim Prod, Coll Food & Agr Sci, Riyadh, Saudi Arabia

关键词： bilberry anthocyanin; Salmonella Typhimurium; immune status; transcriptome; proteome; yellow-feathered chicks

期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：5.2； 五年影响因子：6.2 ）

ISSN：

年卷期： 2023 年 14 卷

页码：

收录情况： SCI

摘要： Introduction: The present study investigated the effects of bilberry anthocyanin (BA) on immune function when alleviating Salmonella Typhimurium (S. Typhimurium) infection in chickens.Methods: A total of 180 newly hatched yellow-feathered male chicks were assigned to three groups (CON, SI, and SI + BA). Birds in CON and SI were fed a basal diet, and those in SI + BA were supplemented with 100 mg/kg BA for 18 days. Birds in SI and SI + BA received 0.5 ml suspension of S. Typhimurium (2 x 10(9) CFU/ml) by oral gavage at 14 and 16 days of age, and those in CON received equal volumes of sterile PBS.Results: At day 18, (1) dietary BA alleviated weight loss of chickens caused by S. Typhimurium infection (P < 0.01). (2) Supplementation with BA reduced the relative weight of the bursa of Fabricius (P < 0.01) and jejunal villus height (P < 0.05) and increased the number of goblet cells (P < 0.01) and the expression of MUC2 (P < 0.05) in jejunal mucosa, compared with birds in SI. (3) Supplementation with BA decreased (P < 0.05) the concentration of immunoglobulins and cytokines in plasma (IgA, IL-1 beta, IL-8, and IFN-beta) and jejunal mucosa (IgG, IgM, sIgA, IL-1 beta, IL-6, IL-8, TNF-alpha, IFN-beta, and IFN-gamma) of S. Typhimurium-infected chickens. (4) BA regulated a variety of biological processes, especially the defense response to bacteria and humoral immune response, and suppressed cytokine-cytokine receptor interaction and intestinal immune network for IgA production pathways by downregulating 6 immune-related proteins.Conclusion: In summary, the impaired growth performance and disruption of jejunal morphology caused by S. Typhimurium were alleviated by dietary BA by affecting the expression of immune-related genes and proteins, and signaling pathways are related to immune response associated with immune cytokine receptors and production in jejunum.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：广东省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台