Soy Isoflavones Protect Neuronal PC12 Cells against Hypoxic Damage through Nrf2 Activation and Suppression of p38 MAPK and AKT-mTOR Pathways
文献类型： 外文期刊
作者： Zhang, Yongzhu 1 ; Yin, Liqing 1 ; Dong, Jiajia 1 ; Xia, Xiudong 2 ;
作者机构： 1.Nanjing Univ Chinese Med, Coll Pharm, Key Res Lab Chinese Med Proc Jiangsu Prov, Nanjing 210023, Peoples R China
2.Jiangsu Acad Agr Sci, Inst Agr Prod Proc, Nanjing 210014, Peoples R China
3.Jiangsu Acad Agr Sci, Key Lab Food Qual & Safety Jiangsu Prov, Minist Sci & Technol,Inst Food Safety & Nutr,Stat, Minist Agr & Rural Affairs,Lab Qual & Safety Risk, Nanjing 210014, Peoples R China
关键词： phenolic compounds; neuroprotective effects; apoptosis; cell cycle; molecular docking analysis
期刊名称：ANTIOXIDANTS （ 影响因子：7.675； 五年影响因子：7.886 ）
ISSN：
年卷期： 2022 年 11 卷 10 期
页码：
收录情况： SCI
摘要： Isoflavones are a class of major phenolic compounds, derived from soybeans, that possess unique therapeutic and biological properties. The possible mechanisms of isoflavone-mediated protection of neuronal PC12 cells against hypoxic damage was investigated in this study. Isoflavones showed potential neuroprotective effects by increasing cell viability, decreasing the level of reactive oxygen species (ROS), and inhibiting apoptosis and cell cycle arrest in cobalt chloride (CoCl2)-induced hypoxic damage. A Western blot analysis indicated that isoflavones decreased apoptosis by up-regulating the Bcl-xL protein and down-regulating the Bax protein. They further reduced the S-phase fraction of the cell cycle by down-regulating the p21 protein and up-regulating the cyclin A protein levels. Additionally, isoflavones activated Nrf2 protein translocation and inhibited the p38 MAPK and AKT-mTOR pathways. A molecular docking analysis further revealed that isoflavones displayed a potential competitive interaction with the Nrf2 protein for Keap1. Our findings suggest that isoflavones could be a potent neuroprotective phytochemical in soybeans and their products.
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