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Clinical protective effects of polyhexamethylene biguanide hydrochloride (PHMB) against Vibrio parahaemolyticus causing translucent post-larvae disease (VpTPD) in Penaeus vannamei

文献类型： 外文期刊

作者： Jia, Tianchang 1 ; Xu, Tingting 1 ; Xia, Jitao 1 ; Liu, Shuang 1 ; Li, Wenqiang 1 ; Xu, Ruidong 1 ; Kong, Jie 1 ; Zhang, Qingli 1 ;

作者机构： 1.Chinese Acad Fishery Sci, State Key Lab Mariculture Biobreeding & Sustainabl, Qingdao 266071, Shandong, Peoples R China

2.Chinese Acad Fishery Sci, Key Lab Maricultural Organism Dis Control, Minist Agr, Qingdao 266071, Shandong, Peoples R China

3.Chinese Acad Fishery Sci, Qingdao Key Lab Mariculture Epidemiol & Biosecur, Qingdao 266071, Shandong, Peoples R China

4.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Qingdao 266071, Shandong, Peoples R China

5.Laoshan Lab, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Shandong, Peoples R China

关键词： Translucent post-larvae disease (TPD); VpTPD; PHMB; Toxicity; Protection effect; Penaeus vannamei

期刊名称：JOURNAL OF INVERTEBRATE PATHOLOGY （ 影响因子：3.4； 五年影响因子：3.1 ）

ISSN： 0022-2011

年卷期： 2023 年 201 卷

页码：

收录情况： SCI

摘要： A new emerging disease called "translucent post-larvae disease" (TPD) in Penaeus vannamei, caused by a novel type of highly lethal Vibro parahaemolyticus (VpTPD), has become an urgent threat to the shrimp farming industry in China. In order to develop an effective disinfectant for the prevention and control of the VpTPD, the clinical protective effects of polyhexamethylene biguanide hydrochloride (PHMB) against VpTPD in Penaeus vannamei were investigated by carrying out an acute toxicity test of PHMB on post-larvae of P. vannamei and its effect of treatment test on VpTPD infection. The results showed that the median lethal concentration of disinfectant (LC50) values of PHMB to post-larvae of P. vannamei after treatment for 24 h, 48 h, 72 h, 96 h were 16.13 mg/L (14.18-18.57), 10.77 mg/L (9.93-11.72), 9.68 mg/L (8.53-11.64), 9.14 mg/L (7.70-10.99), respectively. In addition, a clinical trial showed that 1 mg/L PHMB showed a strong protective effect on the post-larvae of shrimp challenged with 101-104 CFU/ml of VpTPD. The relative percentage survival (RPS) of 1 mg/L PHMB on post-larvae of P. vannamei challenged with VpTPD at 101, 102, 103 and 104 CFU/ml were 63.65 %+/- 6.81, 62.96 %+/- 5.56, 60.00 %+/- 3.75 and 66.67 %+/- 3.75 at 96 hours post infection. The results highlight the clinical protective effects of the PHMB and therefor PHMB can be used as a preventive measure to control early TPD infection in shrimp culture. This study also provides valuable information for the prevention of other bacterial diseases in shrimp culture.

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