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Toxicologic effect and transcriptome analysis for sub-chronic exposure to carbendazim, prochloraz, and their combination on the liver of mice

文献类型： 外文期刊

作者： Zhang, Shuwen 1 ; Luo, Ting 2 ; Weng, You 4 ; Wang, Dou 2 ; Sun, Li 1 ; Yu, Zheping 1 ; Zhao, Yao 2 ; Liang, Senmiao 1 ; Ren, Haiying 1 ; Zheng, Xiliang 1 ; Jin, Yuanxiang 4 ; Qi, Xingjiang 1 ;

作者机构： 1.Zhejiang Acad Agr Sci, Inst Hort, Hangzhou 310021, Peoples R China

2.State Key Lab Managing Biot & Chem Threats Qual &, Hangzhou 310021, Peoples R China

3.Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, Minist Agr, Lab Hangzhou Risk Assessment Agr Prod, Hangzhou 310021, Peoples R China

4.Zhejiang Univ Technol, Coll Biotechnol & Bioengn, Hangzhou 310032, Peoples R China

5.Xianghu Lab, Hangzhou 311231, Peoples R China

关键词： Transcriptome; Carbendazim; Prochloraz; Hepatotoxicity; Mice

期刊名称：ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

ISSN： 0944-1344

年卷期： 2024 年 31 卷 4 期

页码：

收录情况： SCI

摘要： Carbendazim (CBZ) and prochloraz (PCZ) are broad-spectrum fungicides used in agricultural peat control. Both fungicides leave large amounts of residues in fruits and are toxic to non-target organisms. However, the combined toxicity of the fungicides to non-target organisms is still unknown. Therefore, we characterized the toxic effects of dietary supplementation with CBZ, PCZ, and their combination for 90 days in 6-week-old male Institute of Cancer Research (ICR) mice. CBZ-H (100 mg/kg day), PCZ-H (10 mg/kg day), and their combination treatments increased the relative liver weights and caused liver injury. The serum total cholesterol (TC), triglyceride (TG), glucose (Glu), pyruvate (PYR), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) levels were reduced, and synergistic toxicity was observed. Hepatic transcriptome revealed that 326 differentially expressed genes (DEGs) of liver were observed in the CBZ treatment group, 149 DEGs in the PCZ treatment group, and 272 DEGs in the combination treatment group. According to KEGG enrichment analysis, the fungicides and their combination affected lipid metabolism, amino acid metabolism, and ferroptosis. In addition, the relative mRNA levels of key genes involved in lipid metabolism were also examined. Compared with individual exposure, combined exposure to CBZ and PCZ caused a more obvious decrease in the expression of some genes related to glycolipid metabolism. Furthermore, the relative mRNA levels of some key genes in the combination treatment group were lower than those in the CBZ and PCZ treated groups. In summary, CBZ, PCZ, and their combination generally caused hepatotoxicity and glycolipid metabolism disorders, which could provide new insights for investigating the combined toxicity of multiple fungicides to animals.

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