Zhaoshumycins A and B, Two Unprecedented Antimycin-Type Depsipeptides Produced by the Marine-Derived Streptomyces sp. ITBB-ZKa6
文献类型： 外文期刊
作者： Guo, Zhikai 1 ; Ma, Shiying 3 ; Khan, Salman 3 ; Zhu, Hongjie 3 ; Zhang, Bo 3 ; Zhang, Shiqing 1 ; Jiao, Ruihua 3 ;
作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou 571101, Hainan, Peoples R China
2.Chinese Acad Trop Agr Sci, Hainan Inst Trop Agr Resources, Hainan Key Lab Conservat & Utilizat Trop Agr Bior, Haikou 571101, Hainan, Peoples R China
3.Nanjing Univ, Sch Life Sci, Inst Funct Biomol, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Peoples R China
关键词： antimycin; depsipeptide; cytotoxic activity;
Streptomyces sp.
; marine actinomycetes期刊名称：MARINE DRUGS （ 影响因子：5.118； 五年影响因子：5.951 ）
ISSN：
年卷期： 2021 年 19 卷 11 期
页码：
收录情况： SCI
摘要： Marine actinomycetes are prolific chemical sources of complex and novel natural products, providing an excellent chance for new drug discovery. The chemical investigation of the marine-derived Streptomyces sp. ITBB-ZKa6, from Zhaoshu island, Hainan, led to the discovery of two unique antimycin-type depsipeptides, zhaoshumycins A (1) and B (2), along with the isolation of the four known neoantimycins A (3), F (4), D (5), and E (6). The structures of the new compounds 1 and 2 were elucidated on the basis of the analysis of diverse spectroscopic data and biogenetic consideration. Zhaoshumycins A (1) and B (2) represent a new class of depsipeptides, featuring two neoantimycin monomers (only neoantimycin D or neoantimycins D and E) linked to a 1,4-disubstituted benzene ring via an imino group. Initial toxicity tests of 1-6 in MCF7 human breast cancer cells revealed that compounds 5 and 6 possess weak cytotoxic activity. Further structure-activity relationship analysis suggested the importance of the NH2 group at C-34 in 5 and 6 for cytotoxicity in MCF7 cells.
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