Exploring the neurotoxic effects of cylindrospermopsin in early development of zebrafish: An integrated impact of oxidative stress, inflammatory response, and apoptosis
文献类型： 外文期刊
作者： Zhang, Xu 1 ; Hu, Jie 3 ; Jian, Jiaxue 1 ; Liu, Haixia 4 ; Zhou, Xuefei 2 ; Zhang, Yalei 2 ; Zou, Guoyan 1 ; Zhou, Li 1 ; Wang, Jian 3 ;
作者机构： 1.Shanghai Acad Agr Sci, Ecoenvironm Protect Res Inst, Shanghai Engn Res Ctr Low Carbon Agr, Shanghai 201403, Peoples R China
2.Tongji Univ, Coll Environm Sci & Engn, State Key Lab Pollut Control & Resource Reuse, Shanghai 200092, Peoples R China
3.Minist Ecol & Environm, Nanjing Inst Environm Sci, Nanjing 210042, Peoples R China
4.Chinese Res Inst Environm Sci, Beijing 100012, Peoples R China
5.Anshun Univ, Coll Agr, Anshun 561000, Guizhou, Peoples R China
关键词： Cylindrospermopsin; Neurotoxicity; Zebrafish; Oxidative damage; N-acetylcysteine
期刊名称：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY （ 影响因子：6.1； 五年影响因子：6.4 ）
ISSN： 0147-6513
年卷期： 2025 年 293 卷
页码：
收录情况： SCI
摘要： The increasing global spread of cyanobacteria and their toxin Cylindrospermopsin (CYN) is a growing concern. This study aimed to examine the toxic effects of CYN on the early neurodevelopment of zebrafish, and to identify the underlying mechanisms. The findings indicated that zebrafish exposed to varying concentrations of CYN exhibited general developmental toxicity, including typical malformations, diminished embryonic movement, and shortened body length. The length of zebrafish larvae was shortened by 4.8 and 6.1 % in the 0.2 and 2 mu m exposure groups, Furthermore, CYN was observed to impede neuronal development and motor behaviour in zebrafish. Concomitantly, CYN markedly elevated reactive oxygen species (ROS) levels and modified catalase (CAT) and superoxide dismutase (SOD) activities. Compared with the control group, zebrafish larvae in the 0.2 and 2 mu m exposure groups showed a significant decrease of 17.7 and 43.2 % in CAT activity and a significant increase of 51.4 and 84.4 % in SOD activity, indicating that CYN induces oxidative stress. Furthermore, the fluorescence quantification and acridine orange staining assay conducted on additional Tg(lyz:dsRed) transgenic lines provided further evidence that CYN induced an inflammatory response and apoptosis, a finding that was also verified at the gene level. This study not only provides new insights into the mechanisms of CYN toxicity, but also provides important scientific evidence for risk assessment of environmental pollutants and the conservation of aquatic organisms.
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