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FAdV-4 induces more severe inflammatory responses compared to FAdV-8b

文献类型： 外文期刊

作者： Sun, Qinqin 1 ; Lei, Xingfen 1 ; Zhang, Lianshun 1 ; Cheng, Zilong 3 ; Liu, Sidang 4 ; Fu, Qiang 1 ;

作者机构： 1.Foshan Univ, Sch Anim Sci & Technol, Foshan, Peoples R China

2.Foshan Univ, Vet Teaching Hosp, Foshan, Peoples R China

3.Jiangsu Acad Agr Sci, Minist Agr, Inst Vet Med, Key Lab Vet Biol Engn & Technol, Nanjing 210014, Peoples R China

4.Shandong Agr Univ, Coll Anim Sci & Technol, Tai An 271018, Shandong, Peoples R China

关键词： FAdV-4; FAdV-8b; Inflammatory response

期刊名称：POULTRY SCIENCE （ 影响因子：4.2； 五年影响因子：4.5 ）

ISSN： 0032-5791

年卷期： 2025 年 104 卷 11 期

页码：

收录情况： SCI

摘要： Multiple infections, either single or mixed, involving pathogens such as serotype 4 fowl adenovirus (FAdV-4) and serotype 8b fowl adenovirus (FAdV-8b), have been observed in numerous laying hens in China, leading to severe liver damage. Thus, fowl adenovirus (FAdVs) is speculated to cause and inflammatory response. In this study, single infections with FAdV-4 and FAdV-8b were confirmed through RT-PCR and Enzyme-linked Immunosorbent Assay (ELISA) in specific pathogen-free (SPF) chickens exhibiting severe liver damage. Following this, the two reference strains, FAdV-4 and FAdV-8b, were inoculated into cardiomyocytes (CM) and cardiac fibroblasts (CF) to assess their immune responses. Additionally, the replication dynamics of FAdV-4 and FAdV-8b, as well as the expression levels of immune-related cytokines, were evaluated. The results demonstrated that FAdV-4 significantly enhanced viral replication in the heart, CM, and CF cells. The transcriptional levels of IL-1(3, TNF alpha, IL-6, and IL-8 were markedly increased in cells infected with either FAdV-4 or FAdV-8b. These findings confirmed the in vitro and in vivo infection of FAdV-4 and FAdV-8b, elucidating their pathogenic mechanisms and providing new insights into the viral interactions and immune responses.

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