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Citrus maxima and tea regulate AMPK signaling pathway to retard the progress of nonalcoholic fatty liver disease

文献类型： 外文期刊

作者： Wen, Shuai 1 ; An, Ran 2 ; Li, Zhi-Gang 1 ; Lai, Zhao-Xiang 1 ; Li, Dong-Li 2 ; Cao, Jun-Xi 1 ; Chen, Ruo- Hong 1 ; Zhang, Wen-Ji 1 ; Li, Qiu-Hua 1 ; Lai, Xing-Fei 1 ; Sun, Shi-Li 1 ; Sun, Ling-Li 1 ;

作者机构： 1.Guangdong Acad Agr Sci, Guangdong Key Lab Tea Resources Innovat & Utiliza, Tea Res Inst, Guangzhou, Peoples R China

2.Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen, Peoples R China

3.Int Healthcare Innovat Inst Jiangmen, Jiangmen, Peoples R China

关键词： nonalcoholic fatty liver disease; tea; Citrus maxima; AMPK

期刊名称：FOOD & NUTRITION RESEARCH （ 影响因子：3.221； 五年影响因子：4.739 ）

ISSN： 1654-6628

年卷期： 2022 年 66 卷

页码：

收录情况： SCI

摘要： Background: Nonalcoholic fatty liver disease (NAFLD) is a chronic metabolic disease that easily induces hepatitis, cirrhosis, and even liver cancer. The long-term use of NAFLD therapeutic drugs produces toxicity and drug resistance. Therefore, it is necessary to develop high efficiency and low-toxicity active ingredients to alleviate NAFLD. Objective: This study aimed to reveal the role and mechanism of a new functional food CMT in alleviating NAFLD. Results: In the ob/ob fatty liver mice models, the CMT extracts significantly inhibited the weight gain of the mice and reduced the accumulation of white fat. The anatomical and pathological results showed that CMT relieved fatty liver in mice and reduced excessive lipid deposition and inflammatory infiltration. Serological and liver biochemical indicators suggest that CMT reduced dyslipidemia and liver damage caused by fatty liver. CMT obviously activated the adenosine 5'-monophosphate-activated protein kinase (AMPK)/acetyl-coA carboxylase (ACC) and AMPK/fatty acid synthase (FAS) signaling pathways, promoted fat oxidation, and inhibited synthesis. Moreover, CMT regulated the expression of inflammatory factors to relieve hepatitis caused by NAFLD. Conclusion: The study explained the role and mechanism of CMT in alleviating NAFLD and suggested that the active ingredients of CMT might be beneficial in NAFLD therapy.

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