Joint transcriptomics and metabolomics unveil the protective mechanism of tamarind seed polysaccharide against antibiotic-induced intestinal barrier damage
文献类型： 外文期刊
作者： Chen, Yinan 1 ; Li, Xujiao 2 ; Sun, Xianbao 1 ; Kou, Yuxing 1 ; Ma, Xuan 1 ; Song, Lihua 1 ; Zhang, Hui 3 ; Xie, Fan 3 ; Song, Zibo 4 ; Yuan, Chunmei 4 ; Huang, Siyan 4 ; Wu, Yan 1 ;
作者机构： 1.Shanghai Jiao Tong Univ, Sch Agr & Biol, Shanghai 200240, Peoples R China
2.Shanghai Acad Agr Sci, Inst Agrofood Stand & Testing Technol, Lab Qual & Safety Risk Assessment Agroprod Shangha, Minist Agr & Rural Affairs, Shanghai 201403, Peoples R China
3.Univ Shanghai Sci & Technol, Sch Hlth Sci & Engn, Shanghai 200093, Peoples R China
4.Yunnan Maoduoli Grp Food Co Ltd, Yuxi 653100, Peoples R China
5.Yunnan Special Favor Biotechnol Co Ltd, Yuxi 653100, Peoples R China
关键词： Tamarind seed polysaccharide; Intestinal barrier damage; Transcriptomics; Metabolomics; Clindamycin
期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.5； 五年影响因子：8.7 ）
ISSN： 0141-8130
年卷期： 2025 年 305 卷
页码：
收录情况： SCI
摘要： Intestinal barrier damage is frequently caused by antibiotic therapy, potentially leading to bacterial translocation and toxin leakage, which triggers inflammation and increases the risk of various diseases. In this study, Tamarind seed polysaccharides (TSP) with different molecular weights were administered to mice during the recovery phase from clindamycin-induced intestinal barrier damage. The results indicated that TSP restored the shortened colon length, reduced the enlarged cecum index, and decreased the elevated level of inflammatory infiltration. Biochemical testing revealed that TSP decreased the levels of intestinal permeability biomarkers and inflammatory factors that were elevated by clindamycin treatment. Transcriptomics and non-targeted metabolomics analyses respectively uncovered changes in colon gene expression and fecal metabolites. The joint analysis of these omics data identified critical pathways, including arachidonic acid metabolism, retinol metabolism, and steroid hormone biosynthesis. These findings suggest that TSP could be a promising dietary supplement for protecting the intestinal barrier and alleviating inflammation.
- 相关文献
作者其他论文 更多>>
-
Effects of temperature on the physicochemical properties and volatile profiles of 'Shine Muscat' grape during postharvest storage
作者：Jiang, Zhenghui;Li, Xujiao;Peng, Shuting;Li, Xiaobei;Zhou, Changyan;Zhao, Xiaoyan
关键词：'Shine Muscat' grape; Temperature; Physicochemical properties; Flavor characteristics
-
The impact of supplementation with highland barley in different nutrients on weight loss: The nutrients and function relationship
作者：Xie, Fan;Yan, Yuting;Gao, Xin;She, Haocheng;Wang, Jingyi;Li, Jie;Ai, Lianzhong;Zhang, Jun;Zhang, Zhou;Zhang, Yi
关键词：Highland barley; Different peeling times; Lose weight; Key nutrients
-
Cucumber green mottle mosaic virus encodes additional small proteins with specific subcellular localizations and virulence function
作者：Gong, Pan;Gao, Mengxin;Chen, Yalin;Zhang, Mingzhen;Hu, Xiaohua;Zhao, Siwen;Pan, Mengjiao;Cao, Buwei;Zhou, Xueping;Li, Fangfang;Gao, Mengxin;Zhou, Xueping;Huang, Yucong;Shen, Qingtang;Zhang, Hui;Liu, Yong;Liu, Yong;Lozano-Duran, Rosa;Wang, Aiming
关键词：positive-sense single-stranded RNA viruses; tobamoviruses; cucumber green mottle mosaic virus; small ORFs; peroxisomes; virus pathogenicity
-
The role of multiple C2 domain and transmembrane region proteins in mediating tomato development
作者：Li, Siyi;Ling, Ribin;Liu, Lu;Xuan, Lijie;Li, Siyi;Wu, Xuexia;Zhang, Hui
关键词：Tomato; SlMCTP; Phylogenetic analysis; Hormone response; Main stem apex development
-
Effects of different drying methods on the product quality and key non-volatile compounds of Morchella sextelata
作者：Zhang, Yanmei;Li, Xiaobei;Li, Xujiao;Fan, Tingting;Zhou, Changyan;Zhao, Xiaoyan;Zhao, Zhiyong
关键词：Morchella sextelata; Drying methods; Non-volatile compounds; Appearance differences; Metabolomics
-
Effect of silver nanoparticles on biological nitrogen removal in sequential batch wastewater treatment process: Microbial communities, functional genes, and interactions
作者：Zhu, Yuliang;Zhang, Yan;Liu, Yucan;Zhang, Hui;Sun, Hongwei;Sun, Hongwei;Yang, Lei;Liu, Chengbin;Yang, Xinyi
关键词：Silver nanoparticles; Biological nitrogen removal; Co-occurrence networks; Interaction relationships; Functional genes
-
The Impact of Peeling on Highland Barley's Digestive Properties: In Vitro and In Vivo Insights
作者：Yan, Yuting;Gao, Xin;Xie, Fan;Ai, Lianzhong;Zhang, Yi
关键词：highland barley; digestive properties; peeling; gut microbiota; glycemic index
