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Advancements in SELEX Technology for Aptamers and Emerging Applications in Therapeutics and Drug Delivery

文献类型： 外文期刊

作者： Feng, Liangjie 1 ; Sun, Yu 1 ; Jia, Wenshen 2 ; Yu, Yang 1 ; Liu, Chang 1 ; Yang, Jing 1 ; Luan, Yunxia 2 ; Chen, Jin 1 ; Wang, Fengchao 1 ;

作者机构： 1.Shanghai Inst Technol, Coll Sci, 100 Haiquan Rd, Shanghai 201418, Peoples R China

2.Inst Qual Stand & Testing Technol BAAFS, Beijing 100097, Peoples R China

关键词： aptamer; SELEX; targeted drug delivery; therapeutics; nanotechnology; conjugates

期刊名称：BIOMOLECULES （ 影响因子：4.8； 五年影响因子：5.6 ）

ISSN：

年卷期： 2025 年 15 卷 6 期

页码：

收录情况： SCI

摘要： Nucleic acid aptamers, selected through the Systematic Evolution of Ligands by Exponential Enrichment (SELEX), are short nucleic acid sequences that exhibit high affinity and specificity towards diverse targets. Over the past three decades, substantial advancements have been made in both the technology and applications of nucleic acid aptamers. This review provides an in-depth analysis of the historical development and defining characteristics of aptamers, highlighting recent technological innovations in SELEX, including Capillary Electrophoresis SELEX, Microfluidic SELEX, Cell-SELEX, and others. We explore the applications of aptamers in therapeutic and targeted drug delivery, emphasizing their advantages over traditional antibodies such as cost-effectiveness, ease of synthesis, and lower immunogenicity. Key challenges such as stability, specificity, and efficient delivery are discussed, with proposed strategies for improvement including advanced chemical modifications and integration with nanotechnology. By integrating advanced technologies, aptamers hold significant promise for enhancing precision medicine and personalized therapeutic interventions, offering new avenues for the treatment of complex diseases.

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