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Multi-omics reveals the particle size effect of nanoplastics on the hepatopancreas and intestinal toxicity of crustacean model Neospoda palmata

文献类型： 外文期刊

作者： Han, Mingming 2 ; Zhu, Tian 2 ; Zhou, Zihan 2 ; Li, Yiming 4 ; Yu, Cigang 3 ; Liang, Ji 2 ; Wang, Hong 2 ; Si, Qin 3 ; Jiang, Qichen 1 ;

作者机构： 1.Freshwater Fisheries Res Inst Jiangsu Prov, 79 Chating East Rd, Nanjing 210017, Peoples R China

2.Univ Sains Malaysia, Minden 11800, Penang, Malaysia

3.Minist Environm Protect, Nanjing Inst Environm Sci, Nanjing 210042, Peoples R China

4.Chinese Acad Fisheries Sci, Fishery Machinery & Instrument Res Inst, Shanghai 200092, Peoples R China

关键词： Nano-plastics; Neocaridina palmata; Toxicity mechanisms; Lactobacilli; Toxicity recovery

期刊名称：SCIENCE OF THE TOTAL ENVIRONMENT （ 影响因子：8.2； 五年影响因子：8.6 ）

ISSN： 0048-9697

年卷期： 2024 年 946 卷

页码：

收录情况： SCI

摘要： Nano-plastics (NPs) have emerged as prevalent contaminants in aquatic ecosystems, gaining significant research interest. Nonetheless, limited research has addressed the toxicity mechanisms associated with PS-NPs (polystyrene nanoplastics) of varying particle sizes. In this investigation, genotoxicity, growth patterns, hepatopancreatic damage, and intestinal flora alterations in freshwater shrimp Neocaridina palmata (Shen 1948), , subjected to 35 days PS-NPs exposure (two size PS-NPs: 75 nm and 200 nm were used for this experiment, and five concentrations were set: 0 mg/L, 0.5 mg/L, 2.5 mg/L, 5 mg/L, and 10 mg/L concentrations PS-NP concentrations were examined using RNA sequencing, histopathological analyses, enzyme activity assessments, and 16S rRNA sequencing. Noteworthy variations in differentially expressed genes (DEGs) were identified across groups exposed to different PS-NPs sizes. We observed that PS-NPs predominantly instigated cellular component- related processes and induced apoptosis and oxidative stress across tissues via the mitochondrial pathway. Although the 200 nm-PS-NPs are stronger than the 75 nm-PS-NPs in terms of fluorescence intensity, 75 nm-PSNPs are more likely to promote apoptosis than 200 nm-PS-NPs. PS-NPs impeded standard energy provision in N. palmata, , potentially contributing to decreased body length and weight. Moreover, PS-NPs inflicted damage on intestinal epithelial and hepatopancreatic tissues and significantly modified intestinal microbial community structures. Specifically, PS-NPs-induced intestinal damage was marked by a decline in some probiotics (notably Lactobacilli) ) and a surge in pathogenic bacteria. Moreover, supplementing N. palmata with Lactobacilli appeared ameliorate oxidative stress and strengthen energy metabolism. Our findings provided valuable insights into crustacean toxicity mechanisms when subjected to PS-NPs and the potential risks that different PS-NPs sizes posed to terrestrial ecosystems.

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