Pyridine Derivatives and Furan Derivatives Identified From the Medicinal Mushroom Irpex lacteus SY1002
文献类型： 外文期刊
作者： Yu, Guihong 1 ; Shang, Zhaomeng 1 ; Li, Wanting 1 ; Peng, Jixing 4 ; Mo, Xuhua 1 ; Yang, Song 1 ; Tan, Lingling 1 ;
作者机构： 1.Qingdao Agr Univ, Sch Life Sci, Shandong Prov Key Lab Appl Mycol, Qingdao, Shandong, Peoples R China
2.Qingdao Agr Univ, Qingdao Int Ctr Microbes Utilizing Biogas, Qingdao, Shandong, Peoples R China
3.Jiangsu Ocean Univ, Jiangsu Key Lab Marine Bioresources & Environm, Lianyungang, Jiangsu, Peoples R China
4.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Key Lab Testing & Evaluat Aquat Prod Safety & Qual, Minist Agr & Rural Affairs, Qingdao, Shandong, Peoples R China
关键词：
期刊名称：CHEMISTRY & BIODIVERSITY （ 影响因子：2.5； 五年影响因子：2.6 ）
ISSN： 1612-1872
年卷期： 2025 年 22 卷 6 期
页码：
收录情况： SCI
摘要： Three new pyridine derivatives, irpelactedines A-C (1-3), and a new furan derivative, irpelactedine D (5), along with two structurally related known compounds, irpexidine A (4) and 5-carboxy-2-furanpropanoic acid (6), were isolated from the medicinal fungus Irpex lacteus SY1002. Their structures were elucidated through nuclear magnetic resonance and mass spectral analyses, combined with density functional theory calculations of electronic circular dichroism data. Evaluation of angiotensin-converting enzyme (ACE) inhibitory activity revealed that compounds 1 and 3 displayed moderate inhibition, with IC50 values of 31.49 +/- 3.41 and 80.96 +/- 6.93 mu g/mL, respectively. Molecular docking suggested that compound 1 is bound to the active site of ACE, leading to a reduction in its activity. Furthermore, cytotoxicity and antimicrobial activity tests revealed the low toxicity of these compounds. This is the first report on the ACE inhibitory activity of this class of pyridine derivatives, providing valuable insights into exploring the medicinal potential of I. lacteus and offering a structural template for developing new ACE inhibitors. Future efforts will focus on optimizing their structure and conducting in vivo testing to assess their therapeutic potential.
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