3-Fucosyllactose Prevents Nonalcoholic Fatty Liver Disease by Modulating the Gut Microbiota-Derived Pantothenate in Mice
文献类型： 外文期刊
作者： Liu, Bei 1 ; He, Ningning 1 ; Li, Hui 1 ; Yang, Zizhen 1 ; Lin, Yichen 2 ; Wu, Xiaoyu 1 ; Zhang, Haoyan 1 ; Zhang, Ziheng 1 ; Zhang, Zishuai 1 ; Tian, Yu 3 ; Wu, Zhinan 3 ; Zou, Yuanqiang 3 ; Peng, Jixing 2 ; Li, Shangyong 1 ;
作者机构： 1.Qingdao Univ, Qingdao Med Coll, Sch Basic Med, Qingdao 266071, Peoples R China
2.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Qingdao 266071, Peoples R China
3.BGI Res, Shenzhen 518083, Peoples R China
4.Northwest Univ, Coll Life Sci, Xian 710069, Peoples R China
5.Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China
关键词： nonalcoholic fatty liver disease; gut microbiota; pantothenate; fatty acid biosynthesis; noninvasivediagnostic biomarker
期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.2； 五年影响因子：6.4 ）
ISSN： 0021-8561
年卷期： 2025 年 73 卷 16 期
页码：
收录情况： SCI
摘要： Nonalcoholic fatty liver disease (NAFLD) is a growing global health threat. Human milk oligosaccharides (HMOs) exhibit prebiotic properties that may alleviate NAFLD progression. Herein, our study demonstrates that 3-fucosyllactose (3-FL), a distinctive and crucial HMO, significantly attenuates body weight gain, enhances hepatic lipid metabolism, and reduces inflammation in a high-fat diet (HFD)-induced NAFLD mouse model. These findings suggest its potential as a dietary supplement for preventing and alleviating NAFLD progression. Subsequently, fecal metagenomic and nontargeted metabolomics analyses revealed that 3-FL treatment significantly alleviated HFD-induced gut microbiota dysbiosis, with a specific enhancement of the pantothenate (vitamin B5) metabolic pathways. Our targeted metabolite analysis further revealed a significant increase in both hepatic and fecal pantothenate concentrations, which contributed to the enhancement of the coenzyme A (CoA)-mediated lipid metabolism pathway. Furthermore, the subsequent population cohort analyses revealed a significant correlation between serum pantothenate levels and the progression of NAFLD, thereby reinforcing its candidacy as a noninvasive diagnostic biomarker. These findings show that 3-FL acts as an effective prebiotic to alleviate NAFLD symptoms, in part by enhancing the gut microbiota-mediated pantothenate/CoA metabolic pathway.
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