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Development of controlled-release soy beta-conglycinin nanoparticles containing curcumin using genipin as crosslinker

文献类型： 外文期刊

作者： Liu, Lingling 1 ; Yang, Suhua 1 ; Jin, Linxuan 1 ; Niu, Chenyu 1 ; Liang, Hao 2 ; Chen, Cunkun 3 ; Ban, Zhaojun 1 ;

作者机构： 1.Zhejiang Univ Sci & Technol, Zhejiang Prov Collaborat Innovat Ctr Agr Biol Reso, Sch Biol & Chem Engn, Zhejiang Prov Key Lab Chem & Biol Proc Technol Far, Hangzhou 310023, Peoples R China

2.Beijing Acad Agr & Forestry Sci, Natl Engn Res Ctr Vegetables, Key Lab Urban Agr, Minist Agr & Rural Affairs,Inst Vegetable Sci, Beijing 100097, Peoples R China

3.Tianjin Acad Agr Sci, Inst Agr Prod Preservat & Proc Technol, Natl Engn Technol Res Ctr Preservat Agr Prod,Tianj, Key Lab Postharvest Physiol & Storage Agr Pro Duct, Tianjin 300384, Peoples R China

关键词： Soy beta-conglycinin; Curcumin; Nanoparticle; Bioacessiblity; Anti-cancer function

期刊名称：FOOD BIOSCIENCE （ 影响因子：5.2； 五年影响因子：5.4 ）

ISSN： 2212-4292

年卷期： 2023 年 54 卷

页码：

收录情况： SCI

摘要： Recent advances in nanocarriers for bioactives have focused on finding more sustained-release, natural materials. In this study, genipin-crosslinked soy beta-conglycinin (beta-CG)-curcumin nanoparticles (G-SCP) significantly enhanced the stability of curcumin and released curcumin controllably in the gastric environment. The optimal intra-particle crosslinkage for G-SCP was obtained under the genipin concentration less than 0.2 mg/mL and stirring at 37 degrees C for 24 h, which was confirmed by ninhydrin assay, amino acid analysis, dynamic light scattering (DLS) and flourier transform infrared spectroscopy (FT-IR) analysis. Transmission electron microscopy (TEM), DLS and release of trichloroacetic acid (TCA)-soluble nitrogen were used to systematically evaluate the sustained-release behavior and mechanism of curcumin from the G-SCP. The anti-cancer activity of oral-intake curcumin was investigated by collecting the G-SCP digestion supernatant and analyzing its cellular uptake and proliferation in HepG2 cells. The results revealed that the bioaccessible curcumin released from G-SCP had stronger anti-proliferation for HepG2 cells than free curcumin. On normal liver cells L02, interestingly, bio-accessible curcumin had considerably lower cytotoxicity than it did on HepG2 cells. These findings suggested that the G-SCP was a protein-based carrier that could effectively transfer insoluble bioactives in the gastric environment.

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