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Dietary chitosan alleviates intestinal and liver injury of hybrid sturgeon (Acipenser baerii? ? A. schrenckii?) induced by Aeromonas hydrophila infection

文献类型： 外文期刊

作者： Li, Ruiran 1 ; Wang, Xiaoni 1 ; Yu, Denghang 1 ; Liang, Qianrong 2 ; Liu, Fuguo 4 ; Zhang, Lin 5 ; Hu, Bing 6 ; Wei, Jin 1 ; Liu, Lihe 1 ; Liu, Jun 1 ; Xu, Hongsen 1 ;

作者机构： 1.Wuhan Polytech Univ, Sch Anim Sci & Nutr Engn, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China

2.Zhejiang Fisheries Tech Extens Ctr, Hangzhou 310023, Zhejiang, Peoples R China

3.Zhejiang Fisheries Test & Aquat Dis Prevent Ctr, Hangzhou 310023, Zhejiang, Peoples R China

4.Univ Aberdeen, Scottish Fish Immunol Res Ctr, Sch Biol Sci, Aberdeen AB24 2TZ, Scotland

5.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Wuhan 430223, Peoples R China

6.Fujian Prov Key Lab Special Aquat Formula Feed, Fuqing 350308, Peoples R China

7.Wuhan Polytech Univ, Sch Anim Sci & Nutr Engn, Wuhan 430023, Peoples R China

关键词： Chitosan; Aeromonas hydrophila; Antioxidant capacity; Intestinal morphology

期刊名称：ANIMAL FEED SCIENCE AND TECHNOLOGY （ 影响因子：3.2； 五年影响因子：3.6 ）

ISSN： 0377-8401

年卷期： 2023 年 299 卷

页码：

收录情况： SCI

摘要： Chitosan has been universally used as a feed additive, whereas its regulation on hybrid sturgeon (Acipenser baerii female x Acipenser schrenckii male) after bacterial infection has not been well studied. This study was conducted to investigate the therapeutic intervention with dietary chitosan on alle-viating intestinal and liver injury of hybrid sturgeon induced by Aeromonas hydrophila infection. Healthy sturgeons were pre-challenged by treating with A. hydrophila supplemented diets for 1 week and then fed with diets containing different levels (0.00, 1.00, 3.00 and 5.00 g/kg) of chitosan for 8 weeks. The results showed that there were significant differences (P < 0.05) of FBW, WG, SGR, FI and FCR in sturgeon fed chitosan diets compared to those in fish fed the control diet. Significant enhancement (P < 0.05) of LZM, ACP, AKP and MPO activities were observed in all fish serum therapeutically administrated with chitosan. Compared to control diet, the CAT, SOD and GSH-Px capacity were significantly increased (P < 0.05), and the MDA content was decreased in liver of sturgeons fed chitosan supplemented diets. Moreover, not only mitigate tissue lesions in the liver and intestine, but also visible increase (P < 0.05) of goblet cells in fish mid intestine as well as evident increase (P < 0.05) of the muscular thickness and villus height (except in group CHI1) in fish spiral valve were observed after therapeutic chitosan supple-mentation. The fish therapeutically administrated with 1.00, 3.00 and 5.00 g/kg chitosan conferred 50.00%, 75.00%, 62.50% relative percent survival, respectively, for hybrid sturgeons pre-challenged with A. hydrophila. These results suggested that therapeutic administration of chitosan by sturgeon not only increases their growth performance, antioxidant activity and non-specific immunity but also alleviates intestinal and liver injury in fish challenged by A. hydrophila.

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