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The transmembrane protein TMEM182 promotes fat deposition and alters metabolomics and lipidomics

文献类型： 外文期刊

作者： Chen, Genghua 1 ; Lin, Zetong 1 ; Peng, Haoqi 1 ; Zhang, Shuai 1 ; Zhang, Zihao 1 ; Zhang, Xiquan 1 ; Nie, Qinghua 1 ; Luo, Wen 1 ;

作者机构： 1.South China Agr Univ, Coll Anim Sci, Guangzhou 510642, Guangdong, Peoples R China

2.Minist Agr, Key Lab Chicken Genet Breeding & Reprod, Guangdong Prov Key Lab Agroanim Genom & Mol Breedi, Guangzhou 510642, Guangdong, Peoples R China

3.South China Agr Univ, State Key Lab Livestock & Poultry Breeding, Lingnan Guangdong Lab Agr, Guangzhou 510642, Peoples R China

关键词： TMEM182; Fat formation; Metabolomics; Lipidomics

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.2； 五年影响因子：7.8 ）

ISSN： 0141-8130

年卷期： 2024 年 259 卷

页码：

收录情况： SCI

摘要： TMEM182, a transmembrane protein highly expressed in muscle and adipose tissues, plays a crucial role in muscle cell differentiation, metabolism, and signaling. However, its role in fat deposition and metabolism is still unknown. In this study, we used overexpression and knockout models to examine the impact of TMEM182 on fat synthesis and metabolism. Our results showed that TMEM182 overexpression increased the expression of fat synthesis-related genes and promoted the differentiation of preadipocytes into fat cells. In TMEM182 knockout mice, there was a significant decrease in abdominal fat deposition. RNA sequencing results showed that TMEM182 overexpression in preadipocytes enhanced the activity of pathways related to fat formation, ECMreceptor interaction, and cell adhesion. Furthermore, our analysis using UPLC-MS/MS showed that TMEM182 significantly altered the metabolite and lipid content and composition in chicken breast muscle. Specifically, TMEM182 increased the content of amino acids and their derivatives in chicken breast muscle, promoting amino acid metabolic pathways. Lipidomics also revealed a significant increase in the content of glycerophospholipids, sphingolipids, and phospholipids in the breast muscle after TMEM182 overexpression. These findings suggest that TMEM182 plays a crucial role in regulating fat deposition and metabolism, making it a potential target for treating obesity-related diseases and animal breeding.

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