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LncEDCH1 g.1703613 T>C regulates chicken carcass traits by targeting miR-196-2-3p

文献类型： 外文期刊

作者： Yuan, Rongshuai 1 ; Cai, Bolin 1 ; Ma, Manting 1 ; Zhao, Changbin 1 ; Xian, Yuanrong 1 ; Nie, Qinghua 1 ; Zhang, Xiquan 1 ; Zhang, Dexiang 1 ;

作者机构： 1.South China Agr Univ, Coll Anim Sci, State Key Lab Livestock & Poultry Breeding, Guangdong Lab Lingnan Modern Agr, Guangzhou, Peoples R China

2.Minist Agr & Rural Affairs, Natl Local Joint Engn Res Ctr Livestock Breeding, Key Lab Chicken Genet Breeding & Reprod, Guangdong Prov Key Lab Agroanim Genom & Mol Breedi, Guangzhou, Peoples R China

关键词： LncEDCH1; miR-196-2-3p; single nucleotide polymorphism; carcass trait; chicken

期刊名称：POULTRY SCIENCE （ 影响因子：4.4； 五年影响因子：4.4 ）

ISSN： 0032-5791

年卷期： 2024 年 103 卷 3 期

页码：

收录情况： SCI

摘要： Single nucleotide polymorphisms (SNPs) are valuable genetic markers that can provide insights into the genetic diversity and variation within chicken populations. In poultry breeding, SNP analysis is widely utilized to accelerate the selection of desirable traits, improving the efficiency and effectiveness of chicken breeding programs. In our previous research, we identified an association between LncEDCH1 and muscle development. To further investigate its specific mechanism, we conducted SNP detection and performed genotyping, linkage disequilibrium, and haplotype analysis. Our research findings indicate that 16 SNPs in the LncEDCH1. Among these SNPs, g.1703497 C>T and g.1704262 C>T were significantly associated with breast muscle weight percentage, g.1703497 C>T and g.1703613 T>C were significantly associated with leg weight percentage, and g.1703497 C>T, g.1703589 T>C, g.1703613 T>C, g.1703636 C>A, g.1703768 T>C, g.1704079 C>T, g.1704250 T>C, g.1704253 G>A were significantly associated with skin yellowness. Two haplotype blocks composed of 6 SNPs that were significantly associated with wing skin yellowness, breast skin yellowness, full-bore weight, and carcass weight percentage. Furthermore, through dual-luciferase reporter assays, biotin-coupled miRNA pull-down assays, 5-ethynyl-2 '-deoxyuridine (EDU) assays, immunofluorescence, and quantitative real-time polymerase chain reaction (qPCR), it has been confirmed that miR-196-2-3p inhibits the expression of LncEDCH1 directly by binding to LncEDCH1 g.1703613T>C, thereby achieving indirect regulation of muscle development. These findings provide valuable molecular markers for chicken molecular breeding and broaden our understanding of the regulatory mechanisms.

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