您好，欢迎访问内蒙古农牧业科学院 机构知识库！
内蒙古农牧业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

A dynamic transcriptional cell atlas of testes development after birth in Hu sheep

文献类型： 外文期刊

作者： Su, Jie 1 ; Yang, Yanyan 2 ; Wang, Daqing 3 ; Su, Hong 3 ; Zhao, Feifei 3 ; Zhang, Chuanqiang 4 ; Zhang, Min 3 ; Li, Xiunan 2 ; He, Tingyi 2 ; Li, Xihe 4 ; Tian, Ying 2 ; Song, Biao 6 ; Chen, Chao 7 ; Song, Yongli 5 ; Cao, Guifang 3 ;

作者机构： 1.Inner Mongolia Med Univ, Med Neurobiol Lab, Hohhot 010030, Peoples R China

2.Inner Mongolia Acad Agr & Anim Husb Sci, Hohhot 010000, Peoples R China

3.Inner Mongolia Agr Univ, Key Lab Anim Embryo & Dev Engn Univ Higher Learnin, Hohhot 010018, Peoples R China

4.Inner Mongolia Saikexing Inst Breeding & Reprod Bi, Hohhot 011517, Peoples R China

5.Inner Mongolia Univ, Res Ctr Anim Genet Resources Mongolia Plateau, Hohhot 010021, Peoples R China

6.Inner Mongolia Univ Finance & Econ, Hohhot 010051, Peoples R China

7.Med Intelligent Diagnost Big Data Res Inst, Hohhot 010020, Peoples R China

关键词： Single-cell RNA sequencing; Hu sheep; Testes; Spermatogenesis

期刊名称：BMC BIOLOGY （ 影响因子：4.5； 五年影响因子：5.4 ）

ISSN：

年卷期： 2025 年 23 卷 1 期

页码：

收录情况： SCI

摘要： BackgroundTestes development is a fundamental process in sexual development and reproduction. The testes undergo dramatic structural changes during development, including the proliferation and differentiation of somatic cells such as Sertoli cells, Leydig cells, and myoid cells, as well as the maturation of spermatogonia. However, little is known about the onset of spermatogenesis and cell proliferation and maturation in the spermatogonial niche in large animals.ResultsWe used single-cell RNA sequencing (scRNA-seq) to profile nearly 100,000 cells from Hu sheep testes across seven developmental stages (birth, prepuberty, puberty, and adulthood). We constructed single-cell transcriptomic atlases and identified distinct spermatogonial subtypes, revealing dynamic gene expression patterns during spermatogenesis. Notably, we observed that two distinct Sertoli cell states converge into a mature population during puberty. Additionally, we identified a common prepubertal progenitor for Leydig and myoid cells, with Leydig cells transitioning through progenitor and immature stages before reaching maturity.ConclusionsOur study provides a comprehensive atlas of Hu sheep testes development, revealing key insights into the dynamic changes and regulatory mechanisms of spermatogenesis and somatic cell maturation from birth to adulthood. These findings offer new perspectives on testicular development in large mammals and support future research on reproductive biology and breeding strategies.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：内蒙古农牧业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台