您好，欢迎访问江苏省农业科学院 机构知识库！
江苏省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

The genomic diversity of Chinese porcine reproductive and respiratory syndrome virus isolates from 1996 to 2009

文献类型： 外文期刊

作者： Li, Bin 2 ; Fang, Liurong 1 ; Liu, Suyan 1 ; Zhao, Fuwei 1 ; Jiang, Yunbo 1 ; He, Kongwang 2 ; Chen, Huanchun 1 ; Xiao, S 1 ;

作者机构： 1.Huazhong Agr Univ, Coll Vet Med, Lab Anim Virol, Div Anim Infect Dis,State Key Lab Agr Microbiol, Wuhan 430070, Peoples R China

2.Jiangsu Acad Agr Sci, Inst Vet Med, Nanjing 210014, Jiangsu Prov, Peoples R China

关键词： GenBank sequence data;viral genome;genetic evolution;genomic diversity;antigenic drift;evolutionary mechanism;North American genotype prevalence

期刊名称：VETERINARY MICROBIOLOGY （ 影响因子：3.293； 五年影响因子：3.599 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Since it was first reported in 1995, porcine reproductive and respiratory syndrome (PRRS) has become one of the most important swine diseases in China. A large number of field PRRSV strains have been isolated from different regions of China at different times, especially after a highly pathogenic PRRSV emerged in 2006. Previous studies based on ORF5 gene sequences revealed extensive genetic diversity among Chinese PRRSV isolates. To fully understand the extent of genetic diversity of PRRSV in China, we determined the genomic sequence of PRRSV WUH1, a highly pathogenic PRRSV isolated in late 2006. Based on the complete genomic sequences of strain WUH1 and 66 other field Chinese PRRSV strains isolated from 1996 to 2009, we further analyzed their genetic diversity. The results showed that all the tested Chinese PRRSV isolates belong to the North American genotype and can be clearly divided into four highly diverse subgenotypes. Furthermore, the analysis supported the concept that the highly pathogenic PRRSV in China emerged by gradual variation and evolution from the Chinese domestic virus. In addition, different deletions within Nsp2, deletion and potential antigenic drift within GP3, and point mutations within GP5, were extensively observed in Chinese PRRSV isolates. Interestingly, in addition to a unique discontinuous deletion of 30 aa in Nsp2, there was a 1 nucleotide deletion in both the 5'UTR and 3'UTR in nearly all highly pathogenic PRRSV isolates. These results will contribute to the elucidation of the evolutionary mechanisms of PRRSV in China

  • 相关文献

[1]Characteristics of the molecular diversity of the outer membrane protein A gene of Haemophilus parasuis. Tang, Cheng,Zhang, Bin,Yue, Hua,Yang, Falong,Hai, Quan,Chen, Xiaofei,Guo, Dingqian,Shao, Guoqing.

[2]Application of Bio-Organic Fertilizer Significantly Affected Fungal Diversity of Soils. Luo, Jia,Ran, Wei,Hu, Jiang,Yang, Xingming,Xu, Yangchun,Shen, Qirong,Luo, Jia.

作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：江苏省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台