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Fractionation, partial characterization and bioactivity of water-soluble polysaccharides and polysaccharide-protein complexes from Pleurotus geesteranus

文献类型： 外文期刊

作者： Zhang, Mei 1 ; Zhu, Lin 1 ; Cui, Steve W. 1 ; Wang, Qi 1 ; Zhou, Ting 1 ; Shen, Hengsheng 2 ;

作者机构： 1.Agr & Agri Food Canada, Guelph Food Res Ctr, Guelph, ON N1G 5C9, Canada

2.Fujian Acad Agr Sci, Agri Food Proc Res Ctr, Fuzhou 350003, Peoples R China

关键词： β-Glucan;Anti-tumour activity;Fractionation;Light scattering;Mushroom polysaccharide

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：6.953； 五年影响因子：6.737 ）

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收录情况： SCI

摘要： Fractionation and purification of mushroom polysaccharides is a critical process for mushroom clinical application. After a hot-water treatment, the crude Pleurotus geesteranus (PG) was further fractionated into four fractions (PG-1, -2, -3, -4) using gradient precipitation with water and ammonia sulphate. By controlling the initial polymer concentration and ratio of solvents, this process produced PG fractions with high chemical uniformity and narrow M_w distribution without free proteins. Structurally, PG-1 and PG-2 are pure homopolysaccharide mainly composed of glucose; and PG-3 and PG-4 are heteropolysaccharide-protein complexes. PG-2, a high M_w fraction mainly composed of glucose presented significant cytotoxicity at the concentration of 200 and 100μg/ml to human breast cancer cells. Here, we report a new mushroom polysaccharides extraction and fractionation method, with which we produced four fractions of PG with PG-2 appearing effective anti-tumour activity.

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