文献类型: 外文期刊
作者: Yang, Jian 1 ; Oshima, Yuji 2 ; Sei, Ito 2 ; Miyazaki, Nobuyuki 3 ;
作者机构: 1.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Key Lab Ecol Environm & Resources Inland Fisherie, Wuxi City 214081, Jiangsu, Peoples R China
2.Kyushu Univ, Grad Sch Bioresource & Bioenvironm Sci, Dept Biosci & Biotechnol, Lab Fisheries Environm Sci, Fukuoka 8128581, Japan
3.Univ Tokyo, Ocean Res Inst, Ctr Int Cooperat, Nakano Ku, Tokyo 1648639, Japan
关键词: tributyltin;tiphenyltin;metabolism;hepatic microsome;dall's porpoise
期刊名称:CHEMOSPHERE ( 影响因子:7.086; 五年影响因子:6.956 )
ISSN:
年卷期:
页码:
收录情况: SCI
摘要: The in vitro metabolism of tributyltin (TBT) and triphenyltin (TPT) by the hepatic microsomal cytochrome P-450 system enzymes of Dall's porpoises (Phocoenoides dalli) was comparatively elucidated with those enzymes of the Sprague Dawley rat in the present study. Our results suggested firstly a limited metabolic capacity for TBT and especially TPT to their metabolites in the Dall's porpoises, and documented a similar mechanism of a relatively stronger metabolic rate of TBT to its metabolites than that of TPT in the micro-some of porpoises and rat. However, the metabolic capacity to degrade both TBT and TPT were much lower in the microsome of porpoises than that in the rats.
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